Chapter 6, Problem 6.84P

Interpretation Introduction

(a)

Interpretation:

It is to be determined how the given deuterium-labeled compound is synthesized from the analogous unlabeled compound, using ${\text{D}}_{\text{2}}\text{O}$ as the only source of deuterium.

Concept introduction:

A proton transfer reaction is the one in which a Bronsted Lowry base reacts with a Bronsted Lowry acid. A Bronsted Lowry base is a proton acceptor while a Bronsted Lowry acid is a proton donor. The choice of a base for a given reactant acid is decided by a higher pKa value of the conjugate base. The pKa value for ${\text{D}}_{\text{2}}\text{O}$ is similar to ${\text{H}}_{\text{2}}\text{O}$ (pKa = $15$).

Interpretation Introduction

(b)

Interpretation:

It is to be determined how the given deuterium-labeled compound is synthesized from the analogous unlabeled compound, using ${\text{D}}_{\text{2}}\text{O}$ as the only source of deuterium.

Concept introduction:

A proton transfer reaction is the one in which a Bronsted Lowry base reacts with a Bronsted Lowry acid. A Bronsted Lowry base is a proton acceptor while a Bronsted Lowry acid is a proton donor. The choice of a base for a given reactant acid is decided by a higher pKa value of the conjugate base. The pKa value for ${\text{D}}_{\text{2}}\text{O}$ is similar to ${\text{H}}_{\text{2}}\text{O}$ (pKa = $15$).

Interpretation Introduction

(c)

Interpretation:

It is to be determined how the given deuterium-labeled compound is synthesized from the analogous unlabeled compound, using ${\text{D}}_{\text{2}}\text{O}$ as the only source of deuterium.

Concept introduction:

A proton transfer reaction is the one in which a Bronsted Lowry base reacts with a Bronsted Lowry acid. A Bronsted Lowry base is a proton acceptor while a Bronsted Lowry acid is a proton donor. The choice of a base for a given reactant acid is decided by a higher pKa value of the conjugate base. The pKa value for ${\text{D}}_{\text{2}}\text{O}$ is similar to ${\text{H}}_{\text{2}}\text{O}$ (pKa = $15$).