BIOLOGY CONNECT ACCESS CARD
12th Edition
ISBN: 9781264037452
Author: Raven
Publisher: MCG
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Chapter 6, Problem 2S
Phosphofructokinase functions to add a phosphate group to a molecule of fructose 6-phosphate. This enzyme functions early in glycolysis, an energy-yielding biochemical pathway discussed in chapter 7. The enzyme has an active site that binds fructose and ATP. An allosteric inhibitory site also binds ATP when cellular levels of ATP are very high.
a. Predict the
b. Predict the rate of the reaction if levels of cellular ATP are very high.
c. Describe what is happening to the enzyme when levels of ATP are very high.
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In the mevalonate pathway, three acetyl-CoA are combined to give a C5 product, IPP.A. Write out a 5-step general acid/general base mechanism to explain how HMG-CoA isformed from 3 acetyl-CoA (Note: we are leaving out some details. The enzyme HMG-CoA actuallyuses its Cys residues to accept acetyl groups from 2 acetyl-CoA, making new thioesters and liberatingCoASH) B. Two NADPH and two H+ are required to form mevalonic acid from HMG-CoA. Circle the Hatoms that came from NADPH, and put a square around any H atoms that came from H+.C. Three ATP are used to convert mevalonic acid to IPP. Explain the role of each ATP molecule
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Energy
A
enzyme substrate
enzyme substrate complex
B
+
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enzyme + product
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Reaction progress
2a. Is this reaction spontaneous? Explain your answer.
I
Chapter 6 Solutions
BIOLOGY CONNECT ACCESS CARD
Ch. 6.1 - Prob. 1LOCh. 6.1 - Prob. 2LOCh. 6.1 - Describe the nature of redox reactions.Ch. 6.2 - Explain the laws of thermodynamics.Ch. 6.2 - Prob. 2LOCh. 6.2 - Contrast the course of a reaction with and without...Ch. 6.3 - Describe the role of ATP in short-term energy...Ch. 6.3 - Prob. 2LOCh. 6.4 - Discuss the specificity of enzymes.Ch. 6.4 - Explain how enzymes bind to their substrates.
Ch. 6.4 - Prob. 3LOCh. 6.5 - Prob. 1LOCh. 6.5 - Prob. 2LOCh. 6.5 - Prob. 3LOCh. 6 - Prob. 1DACh. 6 - A covalent bond between two atoms represents what...Ch. 6 - During a redox reaction the molecule that gains an...Ch. 6 - Prob. 3UCh. 6 - A spontaneous reaction is one in which a. the...Ch. 6 - Prob. 5UCh. 6 - Which of the following is NOT a properly of a...Ch. 6 - Where is the energy stored in a molecule of ATP?...Ch. 6 - Prob. 1ACh. 6 - Which of the following statements is NOT true...Ch. 6 - Prob. 3ACh. 6 - Prob. 4ACh. 6 - Enzymes have similar responses to both changes in...Ch. 6 - Prob. 6ACh. 6 - Examine the graph showing the rate of reaction...Ch. 6 - Phosphofructokinase functions to add a phosphate...
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