Microbiology Fundamentals: A Clinical Approach
3rd Edition
ISBN: 9781259709227
Author: Marjorie Kelly Cowan Professor, Heidi Smith
Publisher: McGraw-Hill Education
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Chapter 5, Problem 7Q
The general steps in a viral multiplication cycle are
- a. adsorption, penetration, synthesis, assembly, and release.
- b. endocytosis, uncoating, replication, assembly, and budding.
- c. adsorption, uncoating, duplication, assembly, and penetration.
- d. endocytosis, penetration, replication, maturation, and exocytosis.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
Note that a µCi is a measure of the amount of radioactivity and hence is a measure of the amount of drug present. Given that the oral bioavailability of this drug is known to be essentially 100%, estimate the following from this…
The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 5 Solutions
Microbiology Fundamentals: A Clinical Approach
Ch. 5.1 - Explain what it means when viruses are described...Ch. 5.1 - Identify better terms for viruses than alive or...Ch. 5.1 - Which statements are accurate regarding properties...Ch. 5.2 - Prob. 3AYPCh. 5.2 - Describe the function and structure(s) of viral...Ch. 5.2 - Distinguish between enveloped and naked viruses.Ch. 5.2 - Prob. 6AYPCh. 5.2 - Diagram the possible nucleic acid configurations...Ch. 5.2 - Medical Moment Q. Antibiotics targeting bacteria...Ch. 5.3 - Diagram the five-step life cycle of animal...
Ch. 5.3 - Define the term cytopathic effect and provide one...Ch. 5.3 - Discuss both persistent and transforming...Ch. 5.3 - Provide thorough descriptions of both lysogenic...Ch. 5.3 - Prob. 2NPCh. 5.3 - Prob. 3NPCh. 5.4 - List the three principal purposes of cultivating...Ch. 5.4 - Describe three ways in which viruses are...Ch. 5.4 - Prob. 4NPCh. 5.5 - Prob. 14AYPCh. 5.5 - Prob. 2MMCh. 5.5 - Prob. 5NPCh. 5.6 - Analyze the relative importance of viruses in...Ch. 5.6 - Discuss the primary reason that antiviral drugs...Ch. 5 - ___% of human DNA is thought to consist of viral...Ch. 5 - Prob. 2QCh. 5 - Construct a scenario in which viral latency and...Ch. 5 - Prob. 4QCh. 5 - If viruses that normally form envelopes were...Ch. 5 - Viruses use the host cell cytoplasmic space as...Ch. 5 - The general steps in a viral multiplication cycle...Ch. 5 - Compare and contrast the processes of latency and...Ch. 5 - Pathogenic bacteria lysogenized by phages can...Ch. 5 - When phage nucleic acid is incorporated into the...Ch. 5 - Prob. 11QCh. 5 - Prob. 12QCh. 5 - Prob. 13QCh. 5 - Prob. 14QCh. 5 - Prob. 15QCh. 5 - Prob. 16QCh. 5 - Prob. 17QCh. 5 - Construct an argument for whether humans or...Ch. 5 - Since 2000, the number of orders of viruses...Ch. 5 - Prob. 20QCh. 5 - Prob. 21QCh. 5 - Prob. 1VC
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