(a) Interpretation: Mutation in the human β -globin gene causes sickle-cell disease. A point mutation is the result of a single base substitution in DNA encoding a gene. The sickle- cell mutation results in the substitution of Val for Glu at position 6 in the β - globin protein. By using this information, it has to be explained as to how a point mutation could change a codon for Glu to a codon for Val. Concept introduction: β - globin is also known as HBB hemoglobin. The most common form of hemoglobin is made from alpha and beta globin. It contains 146 amino acids linked together to form a long chain. Pictorial representation:

Question

Biochemistry What is the process of "transamination" in either the muscles or the liver, that involves keto acid or glutamic acid? Please explain how the steps work. Thank you!

Answer 1

Question

Chapter 5, Problem 17P

Interpretation Introduction

(a) Interpretation:

Mutation in the human β -globin gene causes sickle-cell disease. A point mutation is the result of a single base substitution in DNA encoding a gene. The sickle- cell mutation results in the substitution of Val for Glu at position 6 in the β - globin protein. By using this information, it has to be explained as to how a point mutation could change a codon for Glu to a codon for Val.

Concept introduction:

β - globin is also known as HBB hemoglobin. The most common form of hemoglobin is made from alpha and beta globin. It contains 146 amino acids linked together to form a long chain.

Pictorial representation:

Interpretation Introduction

(b) Interpretation:

Mutation in the human β -globin gene caused sickle-cell disease. A point mutation is the result of a single base substitution in DNA encoding a gene. The sickle- cell mutation results in the substitution of Val for Glu at position 6 in the β - globin protein. By using this information, it has to be explainedwhether the pl for the sickle-cell β - globin will be higher or lower than the pl for wild-type β - globin.

Concept Introduction:

β - globin is also known as HBB hemoglobin. The most common form of hemoglobin is made from alpha and beta globin. It contains 146 amino acids linked together to form a long chain.

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