A mixture is made by combining 325 mL of 0 .0200 M Na 2 Cr 2 O 7 with 425 mL of 0 .060 M Fe ( NO 3 ) 2 . Initially, the H + concentration in the mixture is 0.400 M . Dichromate ion oxidizes Fe 2+ to Fe 3+ and is reduced to Cr 3+ . After the reaction in the mixture has ceased, how many milliliters of 0.0100 M NaOH will be required to neutralize the remaining H + ?
A mixture is made by combining 325 mL of 0 .0200 M Na 2 Cr 2 O 7 with 425 mL of 0 .060 M Fe ( NO 3 ) 2 . Initially, the H + concentration in the mixture is 0.400 M . Dichromate ion oxidizes Fe 2+ to Fe 3+ and is reduced to Cr 3+ . After the reaction in the mixture has ceased, how many milliliters of 0.0100 M NaOH will be required to neutralize the remaining H + ?
A mixture is made by combining
325 mL of 0
.0200
M
Na
2
Cr
2
O
7
with
425 mL of 0
.060
M
Fe
(
NO
3
)
2
. Initially, the
H
+
concentration in the mixture is 0.400 M. Dichromate ion oxidizes
Fe
2+
to Fe
3+
and is reduced to
Cr
3+
. After the reaction in the mixture has ceased, how many milliliters of 0.0100 M NaOH will be required to neutralize the remaining
H
+
?
Kumada Coupling:
1. m-Diisobutylbenzene below could hypothetically be synthesized by Friedel-Crafts reaction. Write out the reaction with a
mechanism and give two reasons why you would NOT get the desired product.
Draw the reaction (NOT a mechanism) for a Kumada coupling to produce the molecule above from m-dichlorobenzene.
Calculate the theoretical yield for the reaction in question 2 using 1.5 g of p-dichlorobenzene and 3.0 mL isobutyl bromide.
What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What
other impurities are present in your product and how do you know?
Wintergreen from Aspirin:
1. In isolating the salicylic acid, why is it important to press out as much of the water as possible?
2. Write the mechanism of the esterification reaction you did.
3.
What characteristic absorption band changes would you expect in the IR spectrum on going from aspirin to salicyclic acid and
then to methyl salicylate as you did in the experiment today? Give approximate wavenumbers associated with each functional
group change.
What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What
other impurities are present in your product and how do you know?
Synthesis of ZybanⓇ:
1. Write a mechanism for the bromination of m-chloropropiophenone.
Br₂
CH2Cl2
Cl
Br
2. Give the expected m/z (to a round number) for the molecular ion from the product above (including isotopic peaks).
3. What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What
other impurities are present in your product and how do you know?
Genetic Analysis: An Integrated Approach (3rd Edition)
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