The ABO, Rhesus (Rh) and MN blood group systems. Determination of the following aspects from the given information: a. The genotypes for a child with a blood group – A, Rh - , M Woman – O, Rh - , MN Man – A, Rh + , M. b. The proportion of children born to a man with genotype I A I B Rr MN and woman with I A i Rr NN will have blood types B Rh - MN. c. Paternity of a child having blood group O Rh- MN with a man having blood group B Rh + N, a woman with A Rh + MN. Introduction: A) ABO blood group system- The human blood group system is classified using antigens present on the RBC's (Red blood cells or erythrocyte). ABO blood types were revealed by the Austrian physician Karl Landsteiner (1901). ABO blood group is characterized under multiple alleles that show three or more alternative forms of a gene present on the same locus. B) Rh blood group system: Rhesus factor or Rhesus antigen is another isoantigen of RBC. It is the second most blood group system after ABO blood group system. The “Rh” factor is first described in Rhesus monkeys. The expression of Rh factors is denoted in Rh + - expressed (antigen present), Rh - - deletion of the protein leads to the suppression of antigen (absence of antigen). The Rh factor is crucial during transfusion of blood from a donor to a recipient. If the donor's Rh factor does not match with that of the recipient, it will lead to a transfusion reaction that causes hemolytic anemia. During pregnancy, Rh factor testing is very essential. - Rh + can accept the donation of either Rh + or Rh - . - Rh - can only accept Rh- blood, or it will agglutinate. C) MN blood group system- MN blood group is discovered by Landsteiner and Levine. The MN Blood groups genes are closely linked genes present on chromosome 4. The alleles M and N show co-dominance that can have both phenotypes (MM, MN, NN).

Question

Want to see the full answer?

Answer 1

Question

Chapter 4, Problem 9P

Summary Introduction

To analyze:

The ABO, Rhesus (Rh) and MN blood group systems.

Determination of the following aspects from the given information:

a. The genotypes for a child with a blood group – A, Rh^-, M

Woman – O, Rh^-, MN

Man – A, Rh⁺, M.

b. The proportion of children born to a man with genotype I^AI^B Rr MN and woman with I^Ai Rr NN will have blood types B Rh^- MN.

c. Paternity of a child having blood group O Rh- MN with a man having blood group B Rh⁺ N, a woman with A Rh⁺ MN.

Introduction:

A) ABO blood group system- The human blood group system is classified using antigens present on the RBC's (Red blood cells or erythrocyte). ABO blood types were revealed by the Austrian physician Karl Landsteiner (1901). ABO blood group is characterized under multiple alleles that show three or more alternative forms of a gene present on the same locus.

B) Rh blood group system:

Rhesus factor or Rhesus antigen is another isoantigen of RBC. It is the second most blood group system after ABO blood group system. The “Rh” factor is first described in Rhesus monkeys. The expression of Rh factors is denoted in Rh⁺ - expressed (antigen present), Rh^- - deletion of the protein leads to the suppression of antigen (absence of antigen). The Rh factor is crucial during transfusion of blood from a donor to a recipient.

If the donor's Rh factor does not match with that of the recipient, it will lead to a transfusion reaction that causes hemolytic anemia. During pregnancy, Rh factor testing is very essential.

- Rh ⁺ can accept the donation of either Rh⁺ or Rh^-.

- Rh^- can only accept Rh- blood, or it will agglutinate.

C) MN blood group system-

MN blood group is discovered by Landsteiner and Levine. The MN Blood groups genes are closely linked genes present on chromosome 4. The alleles M and N show co-dominance that can have both phenotypes (MM, MN, NN).

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

If using animals in medical experiments could save human lives, is it ethical to do so? In your answer, apply at least one ethical theory in support of your position.

You aim to test the hypothesis that the Tbx4 and Tbx5 genes inhibit each other's expression during limb development. With access to chicken embryos and viruses capable of overexpressing Tbx4 and Tbx5, describe an experiment to investigate whether these genes suppress each other's expression in the limb buds. What results would you expect if they do repress each other? What results would you expect if they do not repress each other?

You decide to delete Fgf4 and Fgf8 specifically in the limb bud. Explain why you would not knock out these genes in the entire embryo instead.