Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 36, Problem 4CT
Summary Introduction
To explain: Why erythropoietin usage enhance the performance of athletes.
Concept introduction:
Erythropoietin is an important growth factor that induces red blood cell production in blood. It is commonly called as EPO, which is actually a hormone produced by kidney. When the number of circulating RBC decreases or if the oxygen transport does not function, then the nervous system detects the change and passes the signal to liver where erythropoietin production will be increased.
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 36 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 36 - Prob. 1DAACh. 36 - Prob. 2DAACh. 36 - Risks of Hypertension Eleni Rapsomaniki and her...Ch. 36 - Prob. 1SQCh. 36 - Prob. 2SQCh. 36 - Prob. 3SQCh. 36 - Prob. 4SQCh. 36 - Prob. 5SQCh. 36 - Prob. 6SQCh. 36 - Blood flows directly from the left atrium to...
Ch. 36 - Contraction of the _________ drives blood out into...Ch. 36 - Blood pressure is highest in the _______ and...Ch. 36 - In a person at rest, the largest volume of blood...Ch. 36 - Which of the following has the thickest wall? a....Ch. 36 - Prob. 12SQCh. 36 - Which artery carries oxygen-poor blood?Ch. 36 - Prob. 14SQCh. 36 - Match the terms with their definition. _____ bone...Ch. 36 - Suppose a blood clot forms in the leg, then breaks...Ch. 36 - An atrial septal defect is a birth defect in which...Ch. 36 - Prob. 3CTCh. 36 - Prob. 4CT
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