Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 36, Problem 3DAA
Risks of Hypertension Eleni Rapsomaniki and her colleagues analyzed medical records of 1.25 million people in the United Kingdom to see how hypertension affects the risk of cardiovascular disorders. They looked at records of people who at 30 years old had no history of heart disease or stroke, although some had high blood pressure. By looking at which of these people later had a heart attack or stroke, the researchers were able to estimate the lifetime risks of these disorders in people with, and without high blood pressure. FIGURE 36.19 shows the researchers’ estimates of the lifetime risk for heart attack and for transient ischemic attack (TIA), a type of stroke.
FIGURE 36.19 Lifetime risks of heart attack and TIA (a type of stroke), with and without hypertension at age 30. A transient ischaemic attack (TIA), sometimes called a mini-stroke, is caused by a temporary blockage of a blood vessel that supplies blood to the brain.
Which is a person who has hypertension at age 30 more likely to have by age 60, a heart attack or a TIA?
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Kinetics: One-Compartment First-Order Absorption
1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple routes of administration provides greater insight than a single route of administration alone. The following data was collected in 250-g rats following bolus IV, oral (PO), and intraperitoneal (ip) administration.
Using this data and set of graphs, determine:(calculate for each variable)
(a) k, C0, V, and AUC* for the bolus iv data
(b) k, ka, B1, and AUC* for the po data
c) k, ka, B1, and AUC* for the ip data
(d) relative bioavailability for po vs ip, Fpo/Fip
(e)absolute ip bioavailability, Fip
(f) absolute po bioavailability, Fpo
3. A promising new drug is being evaluated in human trials. Based on preliminary human tests, this drug is most effective when plasma levels exceed 30 mg/L. Measurements from preliminary tests indicate the following human pharmacokinetic parameter values: t1/2,elim = 4.6hr, t1/2,abs = 0.34hr, VD = 0.29 L/kg, Foral = 72%. Based on these parameters, estimate the following if a 49 kg woman were to receive a 1000mg oral dose of this drug:
(a) Estimate the plasma concentration of the drug at 1hr, 6 hr, and 20hr after taking the drug ( Concentration estimate)
(b) Estimate the time for maximum plasma concentration (tmax).
(c) Estimate the maximum plasma concentration (Cmax).
(d) Estimate the time at which the plasma level first rises above 30 mg/L. (Note this is a trial and error problem where you must guess a time, plug it into the concentration equation, and determine if it is close to 30 mg/L. Hint: based on part (a) it should be apparent that the answer is less than 1hr.)
(e)…
Chapter 36 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 36 - Prob. 1DAACh. 36 - Prob. 2DAACh. 36 - Risks of Hypertension Eleni Rapsomaniki and her...Ch. 36 - Prob. 1SQCh. 36 - Prob. 2SQCh. 36 - Prob. 3SQCh. 36 - Prob. 4SQCh. 36 - Prob. 5SQCh. 36 - Prob. 6SQCh. 36 - Blood flows directly from the left atrium to...
Ch. 36 - Contraction of the _________ drives blood out into...Ch. 36 - Blood pressure is highest in the _______ and...Ch. 36 - In a person at rest, the largest volume of blood...Ch. 36 - Which of the following has the thickest wall? a....Ch. 36 - Prob. 12SQCh. 36 - Which artery carries oxygen-poor blood?Ch. 36 - Prob. 14SQCh. 36 - Match the terms with their definition. _____ bone...Ch. 36 - Suppose a blood clot forms in the leg, then breaks...Ch. 36 - An atrial septal defect is a birth defect in which...Ch. 36 - Prob. 3CTCh. 36 - Prob. 4CT
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