Biology: The Unity and Diversity of Life (MindTap Course List)
15th Edition
ISBN: 9781337408332
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 34, Problem 3DAA
Effect of BPA on Insulin Secretion Bisphenol A (BPA) is an endocrine disruptor that may increase the risk of type 2 diabetes. Angel Nadal suspected that BPA disrupts insulin
FIGURE 34.11 Effects of BPA and DPN on glucose-stimulated insulin secretion. DPN is a chemical known to bind and activate estrogen receptors on pancreatic cells. A glucose concentration of 8 millimolar (mM) is equivalent to that of the blood after a meal.
How were the effects or DPN and BPA similar? How did they differ?
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1. In vivo testing provides valuable insight into a drug’s kinetics. Assessing drug kinetics following multiple different routes of administration provides greater insight than just a single route of administration alone. The following data was collected in 250 g rats following bolus iv, oral (po), and intraperitoneal (ip) administration.Using this data and set of graphs, determine:
(a) k, C0, V, and AUC* for the bolus iv data (b) k, ka, B1, and AUC* for the po data (c) k, ka, B1, and AUC* for the ip data (d) relative bioavailability for po vs ip, Fpo/Fip (e) absolute po bioavailability, (f)Fpo absolute ip bioavailability, Fip
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2. Drug quantification from plasma is commonly performed by using techniques such as HPLC or LC/MS. However, these methods do have limitations, and investigators may choose to use a radiolabeled analog of a drug instead. Radioligands are molecules that contain radioactive isotopes, commonly 3H or 14C. This technique allows investigators to quantify drug concentration from radiation measurements. The following measurements were made in 250 g rats following oral administration of 18.2 µCi of a 14C-labeled drug of interest: Time (min) Plasma Radiation Levels (µCi/L) 0 0.0 2 9.7 4 19.2 7 25.3 9 37.8 12 39.6 14 45.8 17 48.8 20 52.0 25 56.4 30 59.2 35 60.1 40 61.1 45 62.1 50 62.8 60 63.1 70 62.1 80 60.1 90 57.3 100 55.5 110 53.7 120 52.2 150 48.0 180 45.0 240 39.0
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The current nutrition labelling regulation in Hong Kong requires food manufacturer to list E+7 information on the package of pre-packaged food products. Do you think that more nutrients, such as calcium and cholesterol, shall be included?
Chapter 34 Solutions
Biology: The Unity and Diversity of Life (MindTap Course List)
Ch. 34 - Prob. 1DAACh. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Effect of BPA on Insulin Secretion Bisphenol A...Ch. 34 - Prob. 1SQCh. 34 - A ________ is synthesized from cholesterol and can...Ch. 34 - Match each pituitary hormone with its target. ____...Ch. 34 - Releasing hormones secreted by the hypothalamus...Ch. 34 - Prob. 5SQCh. 34 - Low blood calcium triggers secretion by ________....
Ch. 34 - _______ lowers blood sugar levels; ________ raises...Ch. 34 - Prob. 8SQCh. 34 - The ________ has both endocrine and exocrine...Ch. 34 - Prob. 10SQCh. 34 - Secretion of _______ suppresses immune responses....Ch. 34 - Prob. 12SQCh. 34 - Which of the following is not a steroid hormone?...Ch. 34 - True or false? All hormones secreted by arthropods...Ch. 34 - Match the term listed at left with the most...Ch. 34 - Women who have been blind since birth almost never...Ch. 34 - A diabetic who injects too much insulin can lose...Ch. 34 - Endocrine disruptors can interfere with biological...Ch. 34 - An arctic hares coat color changes from white to...
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