Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Chapter 3, Problem 26P
In humans, SRY is located near a pseudoautosomal region (PAR) of the Y chromosome, a region of homology between the X and Y chromosomes that allows them to synapse during meiosis in males and is a region of crossover between the chromosomes. The diagram below shows SRY in relation to the pseudoautosomal region.
About 1 in every 25,000 newborn infants is born with sex reversal; the infant is either an apparent male, but with two X chromosomes, or an apparent female, but with an X and a Y chromosome. Explain the origin of sex reversalin human males and females involving the SRY gene. (Hint: See Experimental Insight 3.1 for a clue about the mutational mechanism.)
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Butterflies have an X-Y sex-determination system that is different from that of flies or humans. Female butterflies may be either XY or X0, while butterflies with two or more X chromosomes are males. This photograph shows a tiger swallowtail gynandromorph, which is half male (left side) and half female (right side). Given that the first division of the zygote divides the embryo into the future right and left halves of the butterfly, propose a hypothesis that explains how nondisjunction during the first mitosis might have produced this unusual-looking butterfly.
Question is also in the picture.
A male Drosophila melanogaster has the genotype A/a; B/b; C/c; XD/Y (all genes are on separate chromosomes). How many different sperm genotypes can it produce through meiosis of one single pre-gametic (2n) cell? (remember, there is no crossing over in male Drosophila)
Explain.
Consider a cell with 2 pairs of homologous chromosomes where Chromosome 1 with genes VWXYZ is the homolog of Chromosome
2 with genes vwxyz while Chromosome 3 with genes PQRST is the homolog of Chromosome 4 with genes parst. If a reciprocal
translocation occurred between Chromosome 1 YZ genes and Chromosome 3 ST genes, give the following gamete types produced
after meiosis: (Answer in Arabic numbers only)
1. Gamete/s with non-recombinant chromosomes
2. Gamete/s with 1 recombinant chromosome
3. Gamete/s with 2 recombinant chromosomes
4. Gamete/s with gene duplications
5. Gamete/s with gene deletions
6. Gamete/s with 2 normal chromosome sequences
7. Gamete/s with 1 normal chromosome sequence
8. Gamete/s with balanced translocation
9. Gametes/ with all dominant genes
10. Gamete/s with all recessive genes
11. Gamete/s with 10 different genes
12. Gamete/s with TSXWV genes
13. Gamete/s with vwxyz genes
14. Gamete/s with pqrst genes
15.Gamete/s with PORYZ
Chapter 3 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 3 - Examine the following diagrams of cells from an...Ch. 3 - Our closest primate relative, the chimpanzee, has...Ch. 3 -
3. In a test of his chromosome theory of...Ch. 3 - Cohesion between sister chromatids, as well as...Ch. 3 - 5. The diploid number of the hypothetical animal...Ch. 3 - 6. An organism has alleles R1 and R2 on one pair...Ch. 3 - Explain how the behavior of homologous chromosomes...Ch. 3 - 8. Suppose crossover occurs between the homologous...Ch. 3 -
9. Alleles A and a are on one pair of autosomes,...Ch. 3 - Prob. 10P
Ch. 3 - Describe the role of the following structures or...Ch. 3 - A womans father has ornithine transcarbamylase...Ch. 3 - In humans, hemophilia A (OMIM 306700) is an...Ch. 3 -
14. A wild-type male and a wild-type female...Ch. 3 - 15. A woman with severe discoloration of her tooth...Ch. 3 - 16. In a large metropolitan hospital, cells from...Ch. 3 - In cats, tortoiseshell coat color appears in...Ch. 3 - 18. The gene causing Coffin–Lowry syndrome (OMIM...Ch. 3 - 19. Four eye-color mutants in Drosophila—apricot,...Ch. 3 - 20. For each pedigree shown,
a. Identify which...Ch. 3 - 21. Use the blank pedigrees provided to depict...Ch. 3 - 22. Figure 3.22 (page 89) illustrates reciprocal...Ch. 3 - 23. In fruit flies, yellow body (y) is recessive...Ch. 3 - 24. In a species of fish, a black spot on the...Ch. 3 - LeschNyhan syndrome (OMIM 300322) is a rare...Ch. 3 - 26. In humans, SRY is located near a...Ch. 3 - 27. In an 1889 book titled Natural Inheritance...Ch. 3 - 28. In Drosophila, the X-linked echinus eye...Ch. 3 - 29. A wild-type Drosophila male and female are...Ch. 3 - 30. Drosophila has a diploid chromosome number of...Ch. 3 - The cell cycle operates in the same way in all...Ch. 3 - 33. Form a small discussion group and decide on...Ch. 3 - 34. Duchenne muscular dystrophy (DMD; OMIM 310200)...Ch. 3 - Prob. 35P
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- In Drosophila, the X chromosomes may become attached to one another (XXn ) such that they always segregate together. Some flies thus contain a set of attached X chromosomes plus a Y chromosome. (a) What sex would such a fly be? Explain why this is so. (b) Given the answer to part (a), predict the sex of the off-spring that would occur in a cross between this fly and a normal one of the opposite sex. (c) If the offspring described in part (b) are allowed to interbreed, what will be the outcome?arrow_forwardThe STR DNA marker DS11 is located on the p arm of the chromosome #8 in humans. Molecular analysis has shown that Charlie Chaplin is a heterozygote for the STR marker (genotype DS11A and DS11B) Using this knowledge, provide a diagram of meiosis showing only the movements of chromosome 8 (assume no nondisjunction). Throughout, indicate where the marker may be found (in other words, label the chromosome to show where the STR markers can be found. (Show ONLY the chromosomes at interphase, metaphase 1, end of meiosis 1, metaphase 2, and end of meiosis 2). Suppose Charlie conceived a son with a chromosome 8 trisomy. Molecular analysis of the STR DS11 marker revealed that his son carried two copies of the DS11A marker and a DS11C marker. Based on the data, determine if the nondisjunction occurred in Charlie or in the mother? Provide your reasoning.arrow_forwardA diploid (2n) trihybrid individual with the genotype AaBbDd can make eight genetically different gametes. 2n = 4 n = 2 (1) A d. ID 1 1 2 2 Gt: AaBbDd Loci A/a and D/d are on chromosome 1 and locus B/b is on chromosome 2. Explain how a gamete containing the alleles A, D and b may be produced by meiosis. Refer specifically to meiotic events occurring during Prophase I, Metaphase I, Anaphase I and Anaphase II. (NB: remember to refer to the organism above). COarrow_forward
- What adjectives can be used to describe a fruit fly that has a total of seven chromosomes because it is missing one copy of chromosome 3?arrow_forwardIn mice, the Sry gene is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. Given this information, propose a model to explain the generation of unusual males who have two X chromosomes (with an Sry-containing piece of the Y chromosome attached to one X chromosome).arrow_forwardIn rice, male sterility is controlled by maternal cytoplasmic elements. This phenotype renders the male part of rice plants (i.e. the stamen) unable to produce fertile pollen; the female parts, however, remain receptive to pollination by pollen from male fertile rice plants. However, the presence of a nuclear fertility restorer gene F restores fertility to male-sterile lines. Give the result(s) of the cross and explain the phenotype of the offspring.arrow_forward
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