Concept explainers
(a)
Interpretation:
The hormone released by the body when someone is diagnosed with diabetes and the class of hormone in which it belongs has to be given.
Concept Introduction:
Hormones: Hormones are chemical messengers which are secreted by the cell in endocrine system and are transported along the blood to stimulate the target cells having the corresponding receptors.
Hormones are of three types,
- 1. Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain
functional group ,carboxylic acid group, amino group or by the replacement of a hydrogen atom by heteroatom. - 2. Polypeptides: Polypeptides are organic
polymers having several amino acids attached to each other in a chain. - 3. Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
Insulin is an example for a polypeptide hormone consisting of 51 amino acids. The insulin is generated by pancreas and is functioned at the cell so that the cells take glucose for the generation or storage of energy.
(b)
Interpretation:
The part of body where insulin is generated has to be given.
Concept Introduction:
Hormones: Hormones are chemical messengers which are secreted by the cell in endocrine system and are transported along the blood to stimulate the target cells having the corresponding receptors.
Hormones are of three types,
- 1. Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, amino group or by the replacement of a hydrogen atom by heteroatom.
- 2. Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- 3. Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
Insulin is an example for a polypeptide hormone consisting of 51 amino acids. The insulin is generated by pancreas and is functioned at the cell so that the cells take glucose for the generation or storage of energy.
(c)
Interpretation:
The mode in which the hormone is transported to cells that need it to allow glucose to enter has to be given.
Concept Introduction:
Hormones: Hormones are chemical messengers which are secreted by the cell in endocrine system and are transported along the blood to stimulate the target cells having the corresponding receptors.
Hormones are of three types,
- 1. Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, amino group or by the replacement of a hydrogen atom by heteroatom.
- 2. Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- 3. Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
Insulin is an example for a polypeptide hormone consisting of 51 amino acids. The insulin is generated by pancreas and is functioned at the cell so that the cells take glucose for the generation or storage of energy.
(d)
Interpretation:
The hormone is whether expected to enter the cell to carry out its function has to be explained.
Concept Introduction:
Hormones: Hormones are chemical messengers which are secreted by the cell in endocrine system and are transported along the blood to stimulate the target cells having the corresponding receptors.
Hormones are of three types,
- 4. Amino acid derivatives: It is a derivative of an amino acid formed by the reaction at the side chain functional group, carboxylic acid group, amino group or by the replacement of a hydrogen atom by heteroatom.
- 5. Polypeptides: Polypeptides are organic polymers having several amino acids attached to each other in a chain.
- 6. Steroid: Steroids are a type of organic compound having a molecular structure with four rings connected to each other.
Insulin is an example for a polypeptide hormone consisting of 51 amino acids. The insulin is generated by pancreas and is functioned at the cell so that the cells take glucose for the generation or storage of energy.
Want to see the full answer?
Check out a sample textbook solutionChapter 28 Solutions
Pearson eText Fundamentals of General, Organic, and Biological Chemistry -- Instant Access (Pearson+)
- Determine Km and Vmax from the michaelis menten grapharrow_forwardDetermine the Km and Vmax from the lineweuver burk grapharrow_forwardDo schwann cells produce or act as myelin in the peripheral nervous system? I know that they encase and wrap around axons, but where does the myelin come into play?arrow_forward
- The enzyme lactate dehydrogenase (LDH) catalyzes the conversion of pyruvate to lactatein skeletal muscle cells using NAD/NADH during anaerobic “balanced” fermentation.Answer the following questions about this reaction. (a) Write out the two reductive half reactions and indicate the E ̊' for each half reaction. Write out the full balanced reaction for the pyruvate to lactate rxn and indicate the ∆E ̊' for the reaction. (b) What is the free energy change under standard state conditions for thisreaction? Which direction is spontaneous?(c) Assume that in skeletal muscle cells the ratio of [NAD+] to [NADH] is 100, and that the[pyruvate] = 0.40 mM and [lactate] = 4.0 mM. What is the free energy change (∆G')for the conversion of pyruvate to lactate? Indicate the direction in which the reactionis spontaneous under these cellular conditions.arrow_forwardWhy did the authors worry about the temperature-dependent solubility of the carriers in thebilayer? How did the authors determine whether the effect of freezing the lipid bilayer wasto decrease the solubility of the carriers (nonactin and valinomycin) or whether the effectwas to impair their ability to diffuse through the membrane (decrease their mobility)?arrow_forwardKranse et. al. measured the temperature dependence of conductance using membranescontaining the phospholipids glyceryl dipalmitate and glyceryl distearate. Describe themodifications in membrane content that you would employ to: (a) shift the temperature of the phase transition (b) make the ion conductance curve for valinomycin andnonactin more like that of gramicidinarrow_forward
- Obtain the sequence for the 5-HT receptor HTR1A and generate a hydropathy plot usingthe ExPASY tool ProtScale, the appropriate window, and the Kyte-Doolittle weightingalgorithm. How many transmembrane domains are present in this receptor? Attach yourhydropathy plot to your assignment.arrow_forwardCompare and contrast the structural features of the ion carrier valinomycin with those of achannel former like gramicidin. How does structural information help explain the mechanismby which these molecules conduct ions across membranes?arrow_forwardA typical integral membrane protein has a stretch (or stretches) of ~20 hydrophobic aminoacids that form an α-helix that spans the bilayer (as is found in membrane proteins such asglycophorin A and bacteriorhodopsin). Compare and contrast the molecular and structural features of gramicidin with a membrane-spanning α-helix. Explain how gramicidin can forman ion channel when a typical membrane-spanning α-helix cannot (eg, glycophorin A).arrow_forward
- The titration curve of alanine shows the ionization of two functional groups with pK values of 2.34 and 9.69, corresponding to the ionization of the carboxyl and the protonated amino groups, respectively. The titration of di-, tri-, and larger oligopeptides of alanine also shows the ionization of only two functional groups, although the experimental pK values are different. The table summarizes the trend in pK values. Amino acid or peptide Ala Ala-Ala pKj pk₂ 2.34 9.69 3.12 8.30 Ala-Ala-Ala 3.39 8.03 Ala-(Ala)-Ala, n ≥ 4 3.42 7.94 Modify the molecules to show the oligopeptide Ala-Ala-Ala. You can modify the molecules by moving, adding, deleting, or changing atoms, bonds, or charges. C Select c Draw Templates More H с N 0 S Cl H H | | || H CH3 H CH, H CH₂ Complete the statements about the the pK, values of the Ala-Ala-Ala oligopeptide. The pK₁ value of 3.39 is associated with the -COO group of Ala-Ala-Ala. The pK2 value of 8.03 is associated with the -NH group of Ala-Ala-Ala. Erase Q2 Q…arrow_forwardFacts from the bacterium mals and to dept kan apa in a peptide with antidic properties. This peptide complex with the call membrance of other hacterial species, leading in bacterial death The structure of the peptide has been determined from (a) Cmplete acid hydes of the peptide, followed by amino acid analys, yielded quiar anunt of Lan, Om, Pfx, Prxa, and Wall Cmtiti, an amino acid od prosentin pockets but present in some peptides. Com has the tracture H *H,N-CH-CH-CH, -C- COO (b) The weight of the peptide in approximately 1,200 Th (c) The peptide failed to undergo hydrolysis when treated with the Hydrolysis of the carbonyl-terminal residue of a polypeptide une "NH, the year. This call there Pro or the police does not contain a froz (d) Treatment of the peptide with 1-haw-2,4-dicherer (11N1), followed by complete hydrolysis and ched only from and the derivative NO, Н ON NHCHI CH, CH, C coo +NH, (Hint: The 2,4-diphenyl derivative involves the amino group of a side chain rather than the…arrow_forwardElectrophoresis Macmillan Learning Chymotrypsin is a protease with a molecular mass of 25.6 kDa. The figure shows a stained SDS polyacrylamide gel with a single band in lane I and three bands of lower molecular weight in lane 2. Lane I contains a preparation of chymotrypsin and lane 2 contains chymotrypsin pre-treated with performic acid. 1 2 Why does performic acid treatment of chymotrypsin generate three bands in lane 2? ° Chymotrypsin self-digests on the carboxyl-terminal side of phenylalanine, tryptophan, or tyrosine residues. The three peptides are impurities in the original chymotrypsin sample. Performic acid cleaves proteins on the carboxyl-terminal side of lysine and arginine residues. Performic acid cleaves the disulfide bonds holding together the three subunits of chymotrypsin. Correct Answerarrow_forward
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage LearningHuman Biology (MindTap Course List)BiologyISBN:9781305112100Author:Cecie Starr, Beverly McMillanPublisher:Cengage Learning
- Concepts of BiologyBiologyISBN:9781938168116Author:Samantha Fowler, Rebecca Roush, James WisePublisher:OpenStax CollegeEssentials of Pharmacology for Health ProfessionsNursingISBN:9781305441620Author:WOODROWPublisher:Cengage