
Concept explainers
a) NaH then CH3I
Interpretation:
The product formed when estradiol reacts with NaH and then with CH3I is to be given.
Concept introduction:
When treated with NaH and CH3I, The hydrogen of -OH group in alcohols and phenols is replaced by methyl group.
To give:
The product formed when estradiol reacts with NaH and then with CH3I.
b) CH3COCl, pyridine
Interpretation:
The product formed when estradiol reacts with CH3COCl in pyridine is to be given.
Concept introduction:
When treated with CH3COCl in pyridine, the hydrogen of -OH group in alcohols and phenols is replaced by acetyl group.
To give:
The product formed when estradiol reacts with CH3COCl in pyridine.
c) Br2, FeBr3
Interpretation:
The product formed when estradiol reacts with Br2, FeBr3 to be given.
Concept introduction:
Phenols undergo electrophilic substitution reaction (bromination) when treated with Br2, FeBr3 in the ortho and para positions.
To give:
The product formed when estradiol reacts with Br2, FeBr3.
d) Dess-Martin periodinane
Interpretation:
The product formed when estradiol reacts with Dess-Martin periodinate is to be given.
Concept introduction:
Secondary alcohols are oxidized to
To give:
The product formed when estradiol reacts with Dess-Martin periodinate.

Want to see the full answer?
Check out a sample textbook solution
Chapter 27 Solutions
Organic Chemistry
- A mixture of C7H12O2, C9H9OCl, biphenyl and acetone was put together in a gas chromatography tube. Please decide from the GC resutls which correspond to the peak for C7,C9 and biphenyl and explain the reasoning based on GC results. Eliminate unnecessary peaks from Gas Chromatography results.arrow_forwardIs the molecule chiral, meso, or achiral? CI .CH3 H₂C CIarrow_forwardPLEASE HELP ! URGENT!arrow_forward
- Identify priority of the substituents: CH3arrow_forwardHow many chiral carbons are in the molecule? OH F CI Brarrow_forwardA mixture of three compounds Phen-A, Acet-B and Rin-C was analyzed using TLC with 1:9 ethanol: hexane as the mobile phase. The TLC plate showed three spots of R, 0.1 and 0.2 and 0.3. Which of the three compounds (Phen-A; Acet-B or Rin-C) would have the highest (Blank 1), middle (Blank 2) and lowest (Blank 3) spot respectively? 0 CH: 0 CH, 0 H.C OH H.CN OH Acet-B Rin-C phen-A A A <arrow_forward
- Introduction to General, Organic and BiochemistryChemistryISBN:9781285869759Author:Frederick A. Bettelheim, William H. Brown, Mary K. Campbell, Shawn O. Farrell, Omar TorresPublisher:Cengage LearningOrganic ChemistryChemistryISBN:9781305580350Author:William H. Brown, Brent L. Iverson, Eric Anslyn, Christopher S. FootePublisher:Cengage Learning


