(a) Interpretation: The structure of each compound involved in the given solid peptide phase synthesis is to be stated. Concept introduction: Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

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Answer 1

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

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Answer 2

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

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Answer 3

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

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Answer 4

Question

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

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Answer 5

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 6

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 7

Chapter 27, Problem 27.19P

Interpretation Introduction

(a)

Interpretation:

The structure of each compound involved in the given solid peptide phase synthesis is to be stated.

Concept introduction:

Solid phase peptide synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which gives rise to the formation of a dipeptide. This dipeptide is again treated with the amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 8

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 9

Interpretation Introduction

(b)

Interpretation:

A reason as to why Boc group is used on the side chain of the Lys group in the B→C step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 10

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 11

Interpretation Introduction

(c)

Interpretation:

An explanation as to why Boc-Val is used rather than Fmoc-Val in the D→E step of the reaction is to be stated.

Concept introduction:

Solid peptide phase synthesis is a process in which an amino protected amino acid is treated with insoluble resin. After that, the amino acid is deprotected which give rise to the formation of a dipeptide. This dipeptide is again treated with an amino protected amino acid. This cycle is repeated several times and resin is removed by using trifluoroacetic acid.

Answer 12

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Answer 13

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Answer 14

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Answer 15

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains the structure of each compound involved in solid phase peptide synthesis.

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