(a) Interpretation: The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly − Lys − Ala using the solid-phase method is to be stated. Concept introduction: Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 1

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Part II. two unbranched ketone have molecular formulla (C8H100). El-ms showed that both of them have a molecular ion peak at m/2 =128. However ketone (A) has a fragment peak at m/2 = 99 and 72 while ketone (B) snowed a fragment peak at m/2 = 113 and 58. 9) Propose the most plausible structures for both ketones b) Explain how you arrived at your conclusion by drawing the Structures of the distinguishing fragments for each ketone, including their fragmentation mechanisms.

Answer 2

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 3

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 4

Question

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

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Answer 5

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 6

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 7

Chapter 27, Problem 27.18P

Interpretation Introduction

(a)

Interpretation:

The reason as to why the two protecting groups used for lysine in the synthesis of the peptide Gly−Lys−Ala using the solid-phase method is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 8

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 9

Interpretation Introduction

(b)

Interpretation:

The structure of each compound obtained from the coupling and decoupling of resin-bound peptide with their explanation is to be stated.

Concept introduction:

Solid-phase peptide synthesis is a technique that is used for peptide synthesis. The peptide is synthesis from C-terminal to N-terminal. It is reverse in biological cells. In this amino protected amino acid is bound covalently on solid phase material with an ester or amide linkage. Then it is deprotected and reacts with another amino protected amino acid. This cycle continues until the desired peptide is not obtained.

Answer 10

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Answer 11

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Answer 12

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Answer 13

Ch. 27 - Prob. 27.1P Ch. 27 - Prob. 27.2P Ch. 27 - Prob. 27.3P Ch. 27 - Prob. 27.4P Ch. 27 - Prob. 27.5P Ch. 27 - Prob. 27.6P Ch. 27 - Prob. 27.8P Ch. 27 - Prob. 27.9P Ch. 27 - Prob. 27.10P Ch. 27 - Prob. 27.11P

Solution Summary: The author explains solid-phase peptide synthesis, wherein lysine is protected from both the amine and carboxyl groups.

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Chapter 27 Solutions