The rates of the two regulated reactions at very high level of GMP needs to be compared. Concept introduction: The point at that the pathway in purine synthesis forks is when the IMP assembled, so it works as a vital regulative step. High concentrations of GMP inhibit the protein IMP dehydrogenase, preventing the conversion of IMP to GMP. Once this pathway is restrained, the production of GMP can be stopped and AMP can be synthesized.

Question

Which of the following regulatory mechanisms will specifically inhibit pyrimidine synthesis (and not also purine synthesis)? (A) allosteric regulation of aspartate transcarbamoylase by CTP(B) allosteric regulation of aspartate transcarbamoylase by ATP(C) synergistic inhibition of PRPP synthetase by AMP/GMP/IMP(D) synergistic inhibition of PRPP amidotransferase by AMP/GMP/IMP (E) feedback inhibition of ribonucleotide reductase by dATP

Answer 1

Question

Chapter 26, Problem 19P

Interpretation Introduction

Interpretation:

The rates of the two regulated reactions at very high level of GMP needs to be compared.

Concept introduction:

The point at that the pathway in purine synthesis forks is when the IMP assembled, so it works as a vital regulative step. High concentrations of GMP inhibit the protein IMP dehydrogenase, preventing the conversion of IMP to GMP. Once this pathway is restrained, the production of GMP can be stopped and AMP can be synthesized.

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