The Energy Cost of dTTP Synthesis (Integrates with Chapter 20.) Starting from HCO 3 − , glutamine, aspartate, and ribosc-5-P, how many ATP equivalents are consumed in the synthesis of dTTP in a eukaryotic cell, assuming dihydroorotate oxidation is coupled to oxidative phosphorylation? How does this result compare with the ATP costs of purine nucleotide biosynthesis calculated in problem 2?

Biochemistry

6th Edition

ISBN: 9781305577206

Author: Reginald H. Garrett, Charles M. Grisham

Publisher: Cengage Learning

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Chapter 26, Problem 14P

The Energy Cost of dTTP Synthesis (Integrates with Chapter 20.) Starting from HCO 3 − , glutamine, aspartate, and ribosc-5-P, how many ATP equivalents are consumed in the synthesis of dTTP in a eukaryotic cell, assuming dihydroorotate oxidation is coupled to oxidative phosphorylation? How does this result compare with the ATP costs of purine nucleotide biosynthesis calculated in problem 2?

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Chapter 26, Problem 13P

Chapter 26, Problem 15P

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De novo purine biosynthesis is a 10-step pathway that builds the purine rings one atom, or one group of atoms, at a time. The pathway converts 5-phosphoribosyl-1-pyrophosphate (PRPP) to inosine monophosphate (IMP). Identify the nine intermediates on the pathway diagram. 5-phosphoribosyl-1-amine PRPP glycinamide ribonucleotide formylglycinamide rimuclocticke N-succinyl-5-aminoimidazole-4- carboxamide ribonucleotide 5-aminoimidazole-4- carboxamide ribonucleotide Incorrect -CH, H H OH Gn Glu -CH. H 0. CH H glycine + ATP HN HC HC ADP+P OH OH OH 0 -PFI HN (P-Ribose Formy-THF HN THE H HN -Ribose -ATP 6-Ⓡ CH₂ HN HC CH, P-Ribose -ATP ADP+P NH, ADP+P HN NH -Ribose NH, N-formylaminoimidazole-4- carboxamide ribonucleotide formylglycinamidine ribonuclcotide S-aminoimidazole ribonuclotidie ATP ADP+Pi HCO, carboxyanincimidazole ribonucleotide -Ribose H -Ribose H₂O Formyl-THF- ASP Fumarate HC THE 0 N. "NH₂ Ⓒ-Abse NH, NH, -ATP NH -N-CH COO ADP+PI Coo IMP COO NH, 000 Answer Bank

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Solution Summary: The author explains that the number of ATP molecules required in dTTP synthesis needs to be determined and compared with that in the purine nucleotide biosynthesis.

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