Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Textbook Question
Chapter 26, Problem 14P
The Energy Cost of dTTP Synthesis (Integrates with Chapter 20.) Starting from
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Need help
Sesamin is one of the major lignans found in sesame oil. Sesamin-metabolic pathways remain uncharacterized at both the enzyme and gene levels. However, one microorganism showed significant sesamin-degrading activity and was identified as Sinomonas sp. no. 22. A sesamin- metabolizing enzyme named SesA was purified from this strain and characterized. Explain how sesamin methylene transferase was identified and characterized and explain the mechanism. Based on your knowledge, what other assays could be run to characterize this enzyme?
Plz answer correctly do not copy.
Question-
Arsinate binds to reduced thio groups such as those found in cystiene residues in proteins, lipoate or glutathione. The resulting inhibition leads to central nervous system pathologies. The binding of arsinate to the dihydrolipoyl groups inhibits which of the following enzyme(s)?
succinate dehydrogenase
malate dehydrogenase
pyruvate dehydrogenase complex
branched-chain amino acid dehydrogenase complex
isocitrate dehydrogenase
alpha-ketoglutarate dehydrogenase complex
Please help!
Chapter 26 Solutions
Biochemistry
Ch. 26 - Prob. 1PCh. 26 - Prob. 2PCh. 26 - Allosteric Regulation of Purine and Pyrimidine...Ch. 26 - Inhibition of Purine and Pyrimidine Metabolism by...Ch. 26 - Prob. 5PCh. 26 - Allosteric Regulation of Ribonucleotide Reductase...Ch. 26 - Prob. 7PCh. 26 - Prob. 8PCh. 26 - Prob. 9PCh. 26 - Prob. 10P
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- biosynthesis of Thymidine monophosphate from ATP, HCO3-, Gln, Asp, quinone, and methylene THF. Show your work and don’t forget that the conversion of U to T only happens AFTER Ribonucleotide Reductase processes the 2’, 3’ ribose to the 3’ deoxy ribosearrow_forwardDe novo purine biosynthesis is a 10-step pathway that builds the purine rings one atom, or one group of atoms, at a time. The pathway converts 5-phosphoribosyl-1-pyrophosphate (PRPP) to inosine monophosphate (IMP). Identify the nine intermediates on the pathway diagram. 5-phosphoribosyl-1-amine PRPP glycinamide ribonucleotide formylglycinamide rimuclocticke N-succinyl-5-aminoimidazole-4- carboxamide ribonucleotide 5-aminoimidazole-4- carboxamide ribonucleotide Incorrect -CH, H H OH Gn Glu -CH. H 0. CH H glycine + ATP HN HC HC ADP+P OH OH OH 0 -PFI HN (P-Ribose Formy-THF HN THE H HN -Ribose -ATP 6-Ⓡ CH₂ HN HC CH, P-Ribose -ATP ADP+P NH, ADP+P HN NH -Ribose NH, N-formylaminoimidazole-4- carboxamide ribonucleotide formylglycinamidine ribonuclcotide S-aminoimidazole ribonuclotidie ATP ADP+Pi HCO, carboxyanincimidazole ribonucleotide -Ribose H -Ribose H₂O Formyl-THF- ASP Fumarate HC THE 0 N. "NH₂ Ⓒ-Abse NH, NH, -ATP NH -N-CH COO ADP+PI Coo IMP COO NH, 000 Answer Bankarrow_forwardApproximately how much does staphylococcal nuclease (Table) decrease the activation free energy ΔG‡ of its reaction (the hydrolysis of a phosphodiester bond) at 25°C?arrow_forward
- Regulation of Glutamine Synthetase by Covalent Modification Suppose at certain specific metabolite concentrations in vivo the cyclic cascade regulating E. coli glutamine synthetase has reached a dynamic equilibrium where the average state of GS adenylylation is poised atn=6. Predict what change in nwill occur if: [ ATP ] increases, PIIA/PIID increases, [ -KG ]/[ Gln ] increases, [ Pi ] decreases.arrow_forwardPls helparrow_forwardBIOMOLECULES - MULTIPLE CHOICE - Please answer properly QUESTION : In human beings, what is the major control of de novo pyrimidine nucleotide synthesis? A. substrate availability B. competitive inhibition of carbamoyl phosphate synthetase II C. feedback inhibition of glutamine-PRPP amidotransferase D. vailability of N-acetyl glutamatearrow_forward
- Multivitamin B complex are essential compounds that are used as derivatives for compounds necessary for many metabolic activities. Give 3 vitamin B compounds and explain where and how they are used along the metabolic pathway.arrow_forwardLysozyme’s use of aspartic acid and glutamic acid, to break the glycosidic bonds of the eubacterial cell wall (composed of peptidoglycan), illustrates the common enzymatic pattern of: hydrolysis (catabolic), using nonpolar amino acids at the active site hydrolysis (catabolic), using polar amino acids at the active site condensation (anabolic), using nonpolar amino acids at the active site condensation (anabolic), using polar amino acids at the active site all of the abovearrow_forward8 of 15 An enzvme has an all-important histidine residue in its active site such that substitution with an other amino acid would result to the loss of catalytic activity. What are the possible mechanisms by which this histidine residue may facilitate catalysis? I. Acting as proton acceptor. II. Forming of covalent bond with the substrate via an ester bond. III. Serve as stabilizer of electrophilic substrate because of its nucleophilic character. Select the correct response: land II Il and III land IlI I. Il, and IIIarrow_forward
- Please explain parts D and E only. Reposting for continued responses. This is Biochem. Please explain each part thoroughly.arrow_forwardGive typed full explanation not a single word hand written otherwise leave itarrow_forwardI don't understand it. Can u help me? Can u help me to explain this to me, pleasearrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Anaerobic Respiration; Author: Bozeman Science;https://www.youtube.com/watch?v=cDC29iBxb3w;License: Standard YouTube License, CC-BY