Concept explainers
To describe: The structure of and how it binds to DNA and eventually releases it.
Concept introduction: Separation of sister chromatids during cell division (mitosis or meiosis) is regulated by a protein complex called as cohesin. It helps to hold the sister chromatids together until anaphase of the cell cycle. Removal of cohesin complex leads to the separation of sister chromatids.
To describe: The role of cohesin in recombination.
Concept introduction: Separation of sister chromatids during cell division (mitosis or meiosis) is regulated by a protein complex called as cohesion. It helps to hold the sister chromatids together until anaphase of the cell cycle. Removal of cohesin complex leads to the separation of sister chromatids.

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Chapter 25 Solutions
FUNDAMENTALS OF BIOCHEMISTRY-ACCESS
- Show the fate of the proton on the 4-Oxygen molecule of F-1,6-BP.arrow_forwardSodium borohydride (NaBH4) is a potent inhibitor of aldolase. It is known to ONLY inhibit theenzyme when it is complexed with substrate. Treatment of the enzyme alone has no effect.What is the mechanism for this inhibition?arrow_forwardA non-hydrolysable ATP (AMPPNP - below) is ingested by a graduate student on a dare. Whateffects would you anticipate on his metabolism?arrow_forward
- Show the mechanism for the acid-catalyzed formation of an [α-1,6] glycosidic linkagebetween two molecules of α-D-glucopyranose. Please sketch the structure and use arrows showing electron flow!arrow_forwardI am a Biochemistry student and I am confused on how to analyze FRAP Analysis using Excel Spread Sheets. The following spread sheet has my 0 minute data listed at top and the 4 minute data listed on the bottom. Sheet: https://mnscu-my.sharepoint.com/:x:/g/personal/vi2163ss_go_minnstate_edu/EXjrCizWiXRPmpittqZA12IB8EkB5eE8iaRqj_iun-IAtg?rtime=Wo9zPHFY3Ug The formula for FRAP Analysis is: FRAP value = A (4 min sample) - A (0 min sample) over A (4 min 30 uM ascorbic acid) - A (0 min 30 uM ascorbic acid) multiplied by 30 uM and the dilution factor of 1/10arrow_forwardHO Fill in the missing boxes. ON 800 NO NO Glucose ATP NADH Hexokinase 1,3-Bisphosphoglycerate Mg2+ ADP NAD+, Pi Phosphoglucose Isomerase Glucose-6-Phosphate ON 沁 Glyceraldehyde-3-Phosphate HO حلمة ADP ADP Phospho Mg2+ glycerate Dihydroxyacetone Phosphate ATP kinase ATP Phosphoglycerate 3-phosphoglycerate Mutase H₁₂O Fructose-6-Phosphate ATP Mg2+ ADP Fructose-1,6-Bisphosphate 2-phosphoglycerate H₂O Phosphoenolpyruvate ADP Mg2+ ATP Pyruvatearrow_forward
- In a diffraction experiment of a native crystal, intensity of reflection (-1 0 6) is equivalent to the intensity of reflection (1 0 -6). true or false?arrow_forwardin an x-ray diffraction experiment, moving the detector farther away from the crystal will allow collection of reflection of reflections with high Miller indices. true or false?arrow_forwardShow the mechanism for the acid-catalyzed formation of an [α-1,6] glycosidic linkagebetween two molecules of α-D-glucopyranose.arrow_forward
- Label the following polysaccharide derivatives as reducing or nonreducing. a. C. b. HO CH₂OH CH2OH OH OH OH OH OH HOCH₂ OH OH OH HOCH₂ HO HO HO OH OH ΙΟ CH₂OH OH OH "OH OHarrow_forwardFor a red blood cell (erythrocyte) undergoing active glycolysis, briefly explain how increases in concentration of the following factors are likely to affect glycolytic flux. a. ATP b. AMP c. F-1,6-BP d. F-2,6-BP e. Citrate f. Glucose-6-phosphatearrow_forwardThe ∆G°’ for hydrolysis of phosphoenol pyruvate is -62.2 kJ/mol. The standard freeenergy of ATP hydrolysis is -30.5 kJ/mol. A. What is the standard free energy and K eq of the spontaneous reaction betweenADP/ATP and phosphoenol pyruvate. B. Repeat A for F-1,6-BP (∆G°’=-16.7 kJ/mol) and 1,3-BPG (∆G°’=-49.6 kJ/mol)hydrolysis. C. If the ATP and ADP concentrations are 8mM and 1mM respectively, what would bethe ratio of pyruvate/phosphoenolpyruvate at equilibrium?arrow_forward
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