HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
19th Edition
ISBN: 9780135672990
Author: AMERMAN
Publisher: Pearson Custom Publishing
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Chapter 24.8, Problem 2QC
Summary Introduction
To review:
The normal characteristics of urine.
Introduction:
Urine is the fluid that remains in the collecting duct after tubular reabsorption and secretion have occurred. The kidneys can produce urine with a concentration of about 1200 mOsm (milliosmoles). It contains water; ions such as calcium, sodium, chloride; phosphates; sulfates; and
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 24 Solutions
HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
Ch. 24.1 - What are the organs of the urinary system?Ch. 24.1 - 2. What are the basic functions of the kidneys?
Ch. 24.2 - Prob. 1QCCh. 24.2 - 2. What are the three regions of the kidney, and...Ch. 24.2 - Prob. 3QCCh. 24.2 - Trace the sequence of blood flow through the...Ch. 24.2 - Prob. 5QCCh. 24.2 - Prob. 6QCCh. 24.2 - Trace the pathway filtrate takes through the...Ch. 24.3 - Prob. 1QC
Ch. 24.3 - 2. How do tubular reabsorption and tubular...Ch. 24.4 - Prob. 1QCCh. 24.4 - Prob. 2QCCh. 24.4 - Prob. 3QCCh. 24.4 - 4. What is the GFR?
Ch. 24.4 - Prob. 5QCCh. 24.4 - Prob. 6QCCh. 24.4 - 7. How does tubuloglomerular feedback affect the...Ch. 24.4 - Prob. 8QCCh. 24.4 - Prob. 9QCCh. 24.4 - Prob. 10QCCh. 24.4 - How does the sympathetic nervous system affect the...Ch. 24.5 - Prob. 1QCCh. 24.5 - 2. What are the three types of transport...Ch. 24.5 - Prob. 3QCCh. 24.5 - What is obligatory water reabsorption?Ch. 24.5 - How do the permeabilities of the two limbs of the...Ch. 24.5 - Prob. 6QCCh. 24.5 - Prob. 7QCCh. 24.5 - Prob. 8QCCh. 24.6 - Prob. 1QCCh. 24.6 - Prob. 2QCCh. 24.6 - Prob. 3QCCh. 24.6 - Prob. 4QCCh. 24.6 - 5. What three factors allow the kidney to produce...Ch. 24.6 - 6. How is concentrated urine produced?
Ch. 24.8 - 1. What is the normal composition of urine?
Ch. 24.8 - Prob. 2QCCh. 24.8 - 3. What is renal clearance, and what is it used...Ch. 24.9 - Prob. 1QCCh. 24.9 - 2. What are the functions of the ureters and...Ch. 24.9 - Prob. 3QCCh. 24.9 - Prob. 4QCCh. 24.9 - Prob. 5QCCh. 24 - What are the four main organs of the urinary...Ch. 24 - 2. Which of the following is not a physiological...Ch. 24 - Mark the following statements as true or false. If...Ch. 24 - Prob. 4CYRCh. 24 - Prob. 5CYRCh. 24 - Which of the following substances would pass...Ch. 24 - Mark the following statements as true or false. If...Ch. 24 - Fill in the blanks for the following statements:...Ch. 24 - Which of the following is false about the GFR? a....Ch. 24 - The route by which substances are reabsorbed by...Ch. 24 - 11. Fill in the blanks: Glomerular hydrostatic...Ch. 24 - Dilute urine is produced when decreased levels of...Ch. 24 - Prob. 13CYRCh. 24 - Prob. 14CYRCh. 24 - Prob. 15CYRCh. 24 - 16. The GFR may be estimated by measuring the rate...Ch. 24 - Prob. 17CYRCh. 24 - Prob. 1CYUCh. 24 - Prob. 2CYUCh. 24 - Prob. 3CYUCh. 24 - Why must the kidneys establish a concentration...Ch. 24 - 1. Drugs that treat hypertension, or high blood...Ch. 24 - Prob. 2AYKACh. 24 - 3. Deana is a 4-year-old girl with a rare genetic...Ch. 24 - 4. Explain how each of the drugs in question 1...Ch. 24 - 5. What might it mean if you found a high...
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