HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
19th Edition
ISBN: 9780135672990
Author: AMERMAN
Publisher: Pearson Custom Publishing
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Chapter 24.5, Problem 6QC
Summary Introduction
To explain:
The substance that is reabsorbed from the filtrate in the nephron loop.
Introduction:
In proximal tubule, water reabsorption is proportional to reabsorption to the solute. Thus, the filtrate has the same level of concentration power as that of interstitial fluid. In case of the nephron loop, the concentration of the filtrate changes on entering the loop, which is due to the difference in permeabilities of the two limbs of the same.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Chapter 24 Solutions
HUMAN ANA.+PHYS.W/LAB MANUAL >BCI<
Ch. 24.1 - What are the organs of the urinary system?Ch. 24.1 - 2. What are the basic functions of the kidneys?
Ch. 24.2 - Prob. 1QCCh. 24.2 - 2. What are the three regions of the kidney, and...Ch. 24.2 - Prob. 3QCCh. 24.2 - Trace the sequence of blood flow through the...Ch. 24.2 - Prob. 5QCCh. 24.2 - Prob. 6QCCh. 24.2 - Trace the pathway filtrate takes through the...Ch. 24.3 - Prob. 1QC
Ch. 24.3 - 2. How do tubular reabsorption and tubular...Ch. 24.4 - Prob. 1QCCh. 24.4 - Prob. 2QCCh. 24.4 - Prob. 3QCCh. 24.4 - 4. What is the GFR?
Ch. 24.4 - Prob. 5QCCh. 24.4 - Prob. 6QCCh. 24.4 - 7. How does tubuloglomerular feedback affect the...Ch. 24.4 - Prob. 8QCCh. 24.4 - Prob. 9QCCh. 24.4 - Prob. 10QCCh. 24.4 - How does the sympathetic nervous system affect the...Ch. 24.5 - Prob. 1QCCh. 24.5 - 2. What are the three types of transport...Ch. 24.5 - Prob. 3QCCh. 24.5 - What is obligatory water reabsorption?Ch. 24.5 - How do the permeabilities of the two limbs of the...Ch. 24.5 - Prob. 6QCCh. 24.5 - Prob. 7QCCh. 24.5 - Prob. 8QCCh. 24.6 - Prob. 1QCCh. 24.6 - Prob. 2QCCh. 24.6 - Prob. 3QCCh. 24.6 - Prob. 4QCCh. 24.6 - 5. What three factors allow the kidney to produce...Ch. 24.6 - 6. How is concentrated urine produced?
Ch. 24.8 - 1. What is the normal composition of urine?
Ch. 24.8 - Prob. 2QCCh. 24.8 - 3. What is renal clearance, and what is it used...Ch. 24.9 - Prob. 1QCCh. 24.9 - 2. What are the functions of the ureters and...Ch. 24.9 - Prob. 3QCCh. 24.9 - Prob. 4QCCh. 24.9 - Prob. 5QCCh. 24 - What are the four main organs of the urinary...Ch. 24 - 2. Which of the following is not a physiological...Ch. 24 - Mark the following statements as true or false. If...Ch. 24 - Prob. 4CYRCh. 24 - Prob. 5CYRCh. 24 - Which of the following substances would pass...Ch. 24 - Mark the following statements as true or false. If...Ch. 24 - Fill in the blanks for the following statements:...Ch. 24 - Which of the following is false about the GFR? a....Ch. 24 - The route by which substances are reabsorbed by...Ch. 24 - 11. Fill in the blanks: Glomerular hydrostatic...Ch. 24 - Dilute urine is produced when decreased levels of...Ch. 24 - Prob. 13CYRCh. 24 - Prob. 14CYRCh. 24 - Prob. 15CYRCh. 24 - 16. The GFR may be estimated by measuring the rate...Ch. 24 - Prob. 17CYRCh. 24 - Prob. 1CYUCh. 24 - Prob. 2CYUCh. 24 - Prob. 3CYUCh. 24 - Why must the kidneys establish a concentration...Ch. 24 - 1. Drugs that treat hypertension, or high blood...Ch. 24 - Prob. 2AYKACh. 24 - 3. Deana is a 4-year-old girl with a rare genetic...Ch. 24 - 4. Explain how each of the drugs in question 1...Ch. 24 - 5. What might it mean if you found a high...
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