EBK ORGANIC CHEMISTRY
8th Edition
ISBN: 8220102744127
Author: Bruice
Publisher: PEARSON
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Textbook Question
Chapter 23, Problem 36P
The glycine cleavage system is a group of four enzymes that together catalyze the following reaction:
Use the following information to determine the sequence of reactions carried out by the glycine cleavage system:
a. The first enzyme is a PLP-requiring decarboxylase.
b. The second enzyme is aminomethyltransferase. This enzyme has a lipoate coenzyme.
c. The third enzyme synthesizes N5,N10-methylene-THF and also forms +NH4.
d. The fourth enzyme is an FAD-requiring enzyme.
e. The cleavage system also requires NAD+.
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Students have asked these similar questions
2. What class of enzyme would expect to catalyze the following reaction?
H,NCHCNHCHCO
H,NCHCOH
H,0
R
R
a. Oxidoreductase
b. Transferase
c. Hydrolase
d. Lyase
e. Isomerase
Give the name of the enzyme that will most likely catalyze each of the following reactions:
32. Although most enzymes are quite specific, they can catalyze
side reactions with compounds that are structurally similar to
their physiological substrates, but usually at much slower rates.
For example, glyceraldehyde-3-phosphate dehydrogenase
(GAPDH), which normally catalyzes the oxidative
phosphorylation of glyceraldehyde-3-phosphate, can slowly
convert erythrose-4-phosphate, an intermediate in the pentose
phosphate pathway, to 1,4-bisphosphoerythronate:
H
OPO²
H-C-OH
H-C-OH
+NAD
HLC-OPO.
Erythrose-4-
phosphate
GAPDH H-C-CH
H-CHOH
+NADH + H²
H.C-OPO.
1,4-Bisphosphoerythronate
Chapter 23 Solutions
EBK ORGANIC CHEMISTRY
Ch. 23.1 - Prob. 2PCh. 23.1 - Prob. 3PCh. 23.2 - How many conjugated double bonds are there in a....Ch. 23.2 - Instead of adding to the 4a position and...Ch. 23.2 - Prob. 7PCh. 23.3 - Prob. 8PCh. 23.3 - Acetolactate synthase is another TPP-requiring...Ch. 23.3 - Acetolactate synthase transfers the acyl group of...Ch. 23.3 - Prob. 12PCh. 23.5 - Which compound is more easily decarboxylated?
Ch. 23.5 - Prob. 14PCh. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - Explain why the ability of PLP to catalyze an...Ch. 23.5 - The enzyme that catalyzes the C C bond cleavage...Ch. 23.5 - Propose a mechanism for the ,-elimination reaction...Ch. 23.6 - Ethanolamine ammonia lyase, a coenzyme...Ch. 23.6 - Prob. 20PCh. 23.7 - How do the structure of tetrahydrofolate and...Ch. 23.7 - What is the source of the methyl group in...Ch. 23.8 - Thiols such as ethanethiol and propanethiol can be...Ch. 23 - How does the metal ion in carboxypeptidase A...Ch. 23 - Prob. 24PCh. 23 - Prob. 25PCh. 23 - For each of the following reactions, name both the...Ch. 23 - Prob. 27PCh. 23 - When transaminated, the three branched-chain amino...Ch. 23 - What acyl groups have we seen transferred by...Ch. 23 - Propose a mechanism for the following reaction:Ch. 23 - Draw the products of the following reaction, where...Ch. 23 - When UMP is dissolved in T2O, exchange of T for H...Ch. 23 - Dehydratase is a PLP-requiring enzyme that...Ch. 23 - In addition to the reaction mentioned in Section...Ch. 23 - PLP can catalyze both ,-elimination reactions...Ch. 23 - The glycine cleavage system is a group of four...Ch. 23 - Prob. 37PCh. 23 - FADH2 reduces , -unsaturated thioesters to...
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