Chapter 23, Problem 23.70E

Interpretation Introduction

Interpretation:

Malonate is an effective competitive inhibitor of the citric acid cycle and the enzyme inhibited by malonate is to be stated. The explanation for the corresponding answer is to be stated.

Concept introduction:

The citric acid cycle (CAC) is also known as the Krebs cycle. The citric acid cycle is the process in which the pyruvate converts into acetyl $\text{CoA}$ in a closed loop and contains eight steps.

Malonate $\left({}^{-}\text{OOC}-{\text{CH}}_{\text{2}}-{\text{COO}}^{-}\right)$ blocks the active sites of an enzyme succinate dehydrogenase and prevents the substrate from further binding and inhibit the citric acid cycle