Chapter 22.7, Problem 4LTS

Interpretation Introduction

Interpretation: Using ammonia as the only source of nitrogen, the reagents that are used to prepare the given amine have to be found.

Concept Introduction:

The given amine is:

The starting materials that are required to obtain the given product can be analysed by retro analysis:

Retro synthetic analysis:

It is the analysis of the synthetic starting materials for a given compound through its precursors or fragments which are known as synthons. The synthons can be obtained by logical cleavage of the chemical bonds in the compounds. The resulted synthons will be therefore known as logical synthons.

On retro synthetic analysis of the given compound, the synthetic reaction will be predicted to be reductive amination reaction.

Reductive amination reaction:

It is the preparation of amine via conversion of a ketone or an aldehyde into imine in the presence of a reducing agent such as sodium cyanoborohydride ${\text{NaBH}}_{\text{3}}\text{CN}$ .

Example: