Interpretation:
The number of steps in gluconeogenesis which are not the exact reversal of the steps in glycolysis, the kind of conversion of substrate to product involve in each of these processes and the common theme in these reactions should be determined.
Concept Introduction:
Glycolysis: This is the
Gluconeogenesis: This process of synthesis of glucose or glycogen from non-carbohydrate sources is called gluconeogenesis.
Substrate for gluconeogenesis
- Glycogenic amino acid
- Glycerol
- Pyruvate
- Lactate
- Intermediate of TCA cycle.
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FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
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- Gluconeogenesis involves the synthesis of glucose from non-carbohydrate precursors. The organs most active from the perspective of gluconeogenesis are the liver and the kidney, which supply glucose to the organs that cannot synthesize it, yet have a strict need for glucose as an energy source. Gluconeogenesis requires several equilibrium steps of glycolysis to run in the reverse direction. What are the reactants and products when GAPDH runs in the direction of gluconeogenesis Glycolysis as a ten-step pathway from glucose to pyruvate is Favourable. Is gluconeogenesis favourable under standard conditions (ie. is the ΔGo’ for the pathway negative)? c. What is true about the thermodynamics of the regulated steps in glycolysis. Compare ΔG and ΔGo’ for those steps in both directions.arrow_forwardGluconeogenesis is like glycolysis but in reverse. Name the 4 enzymes that are responsible for this process. What is its final product?arrow_forwardIn glycolysis, the conversion of phosphoenolpyruvate (PEP) to pyruvate is considered irreversible. Yet, in gluconeogenesis, this "irreverisble" reaction is bypassed and pyruvate is eventually converted to PEP. Explain how gluconeogenesis bypasses this irreverisble reaction. For full credit, detail: 1) The enzymes required to convert pyruvate to PEP 2) The intermediate that is created 3) The "energetic cost" of the reaction(s) (For instance, is the hydrolysis of a high-energy bond in a nucleotide triphosphate necessary?)arrow_forward
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