(a)
Interpretation:
The conditions that direct pyruvate towards entry into the citric acid cycle should be identified.
Concept Introduction:
Fundamental of Citric acid cycle,
- This is a series of enzyme-catalysed
chemical reactions , which is of central importance in all living cells that use oxygen as part ofcellular respiration . - This cycle initially with the transfer of a two-carbon acetyl group from acetyl-CoA (co-enzyme) to the four-carbon acceptor compound (oxaloacetate) to from a sis-carbon compound like citrate.
- The citrate than goes through a series of chemical transformation, losing two carbonyl groups as the carbon dioxide.
(b)
Interpretation:
The conditions that direct pyruvate was converted into ethanol and
Concept Introduction:
Anaerobic conditions: This process is any organisms that does not require oxygen for growth, it react negatively or even die if free oxygen is present.
This process used for industrial or domestic process to manage waste or to product fuels.
(c)
Interpretation:
The conditions that direct pyruvate was converted into lactate and in which organism (or) tissues are involved in this process, should be identified.
Concept Introduction:
It is the totally of an organism chemical reaction,
Metabolism is an emergent property of life that arises from interactions between molecules within the cell.
The pathway begins with a specific molecule and ends with product.
(d)
Interpretation:
The conditions that direct pyruvate was converted into glucose and in which organism (or) tissues are involved in this process, should be identified.
Concept Introduction:
Gluconeogenesis is the process of formation of glucose from non-carbohydrate precursors.
It is occur in all microorganism,
The process occurs only in liver and kidney, partially occurs in cytoplasm and in mitochondria.
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FUND.OF GEN CHEM CHAP 1-13 W/ACCESS
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- The citric acid cycle is a critical sequence of reactions for energy production, which take place in the matrix of the mitochondria. The reaction cycle requires materials from the cytosol to be converted into acetyl CoA, which represents the starting point of a new cycle. Which of the following statements about acetyl CoA is true? (a) Acetyl CoA is recycled at the end of every cycle. (b) Oxaloacetate is attached to acetyl CoA to feed the citric acid cycle. (c) Triacylglycerol molecules are transported into the mitochondrial matrix and cleaved by lipases to produce acetyl CoA. (d) Oxaloacetate is converted directly into acetyl CoA to feed the citric acid cyclearrow_forwardWhich of these is associated with production of ATP during glycolysis? (Select all that apply) a) Conversion of 1,3-BPG to 3PG b) Conversion of 1,3-BPG to 2,3-BPG c) Conversion of PEP to pyruvate d) Conversion of 2,3-BPG to 2PG e) Phosphorylation of glucosearrow_forwardIn some tissues, glucose 6-phosphate is oxidized to pentose phosphates by the pentose phosphate pathway. a) Which tissues prefer this pathway and why? Explain in detail. b) Due to the fact that glucose 6-phosphate is also an intermediate for the glycolysis pathway, the regulation of glycolysis and pentose phosphate pathway is very important. NADPH plays a crucial role in partitioning of glucose 6-phosphate between glycolysis and the pentose phosphate pathway. Explain this role of NADPH in detail.arrow_forward
- Patients with pyruvate dehydrogenase deficiency show high levels of lactic acid in the blood. However, in some cases, treatment with dichloroacetate (DCA) lowers lactic acid levels. (a) How does DCA act to stimulate pyruvate dehydrogenase activity? (b) What does this suggest about pyruvate dehydrogenase activity in patients who respond to DCA?arrow_forwardIf glutamate were labeled with C-14 at the delta-carbon and added via transamination to the citric acid cycle to produce alpha-ketoglutarate, how long would it take for the compounds containing C-14 to be reduced by 25% (assume 10 seconds per turn of the cycle)?arrow_forwardRegarding cellular metabolism, mark the true statements: (a). Electrons from the oxidation of glycolysis are transferred to O2 in the TCA cycle (b).Flow in the citric acid cycle increases when the intracellular ratio [NADH/NAD+] is high (c).In microbial cells, the glyoxylate pathway indirectly allows the conversion of fatty acids into glucose (d).Anaplerotic reactions are enzymatic reactions whose kinetics do not follow the Michaelis-Menten model. (e).Gluconeogenesis is the pathway of glucose production from different precursors, such as glycerol, some amino acids and lactatearrow_forward
- Determine whether the following statements are true or false:- a) The pentose phosphate pathway of glucose conversion is a supplier of NADPH (H +) for reductive syntheses. b) An overdose of insulin causes hypoglycemia in a patient with diabetes mellitus. c) Fructose-6-phosphate is an allosteric regulator of glycolysis.arrow_forwardDuring gluconeogenesis, the three irreversible steps of glycolysis have to be bypassed. The first step is the conversion of pyruvate to phosphoenolpyruvate. Which of the following statement is false regarding the reaction step? Select one: a. Conversion of oxaloacetate from pyruvate occurs in mitochondria and shuttled into the cytosol. b. Formation of phosphoenolpyruvate requires both ATP and GTP as an energy source. c. Acetyl CoA is an activator of enzyme pyruvate carboxylase. d. This reaction involves two-step process catalyzed by pyruvate carboxylase and phosphoenolpyruvate carboxykinasearrow_forwardThe fatty acid 5,8-cis-pentadecanoic acid (CH3-(CH3)5-CH=CH-CH2-CH=CH-(CH2)3-COOH) is subjected to B-oxidation. (a) Indicate the steps involved in its oxidation to acetyl-CoA and/or other products (NADH, FADH2, etc.). (b) What are the products (and quantities) of its complete oxidation (acetyl-CoA, N ADH, FADH2, etc.)? Be sure that you make clear the source of these products.arrow_forward
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