Microbiology: An Introduction (13th Edition)
13th Edition
ISBN: 9780134605180
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case, Derek Weber, Warner Bair
Publisher: PEARSON
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Textbook Question
Chapter 22, Problem 1R
If Clostridium tetani is relatively sensitive to penicillin, why doesn’t penicillin cure tetanus?
Expert Solution & Answer
Summary Introduction
To review:
Why penicillin does not cure tetanus.
Introduction:
Tetanus is an infectious disease caused by the bacteria named Clostridium tetani. It is a rod-shaped (bacillus), gram-positive, anaerobic, spore-forming bacteria.
Explanation of Solution
The anaerobic bacteria Clostridium tetani is sensitive to penicillin. However, adequate blood flow to the site of infection is necessary for penicillin to attain an optimum concentration at the site and to show maximum effectiveness. The causative pathogen is an obligate anaerobe and the wound by which it enters the body provide them an optimum anaerobic growth condition. Thus, due to the absence of enough blood flow, penicillin does not cure tetanus.
Conclusion
Tetanus infections commonly occur following a puncture wound exposed to the C. tetani bacteria. Contamination of the wound often involves contact with soil, fecal matter, or rusty metal containing the causative pathogen.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
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Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
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F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
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Time (minutes)
Serum Linuron Levels (ug/ml)
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10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
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0.29
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0.22
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Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 22 Solutions
Microbiology: An Introduction (13th Edition)
Ch. 22 - If Clostridium tetani is relatively sensitive to...Ch. 22 - Prob. 2RCh. 22 - Prob. 3RCh. 22 - Prob. 4RCh. 22 - Prob. 5RCh. 22 - Prob. 6RCh. 22 - Prob. 7RCh. 22 - Prob. 8RCh. 22 - Provide evidence that Creutzfeldt-Jakob disease is...Ch. 22 - NAME IT This organism causes meningitis and is...
Ch. 22 - Prob. 1MCQCh. 22 - Prob. 2MCQCh. 22 - Prob. 3MCQCh. 22 - Prob. 4MCQCh. 22 - Prob. 5MCQCh. 22 - Prob. 6MCQCh. 22 - Prob. 7MCQCh. 22 - Prob. 8MCQCh. 22 - Microscopic examination of cerebrospinal fluid...Ch. 22 - Prob. 10MCQCh. 22 - Prob. 1ACh. 22 - Prob. 2ACh. 22 - Prob. 1CAECh. 22 - Prob. 2CAECh. 22 - Prob. 3CAE
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