ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
6th Edition
ISBN: 9781260406092
Author: HARTWELL, Leland, HOOD, Leroy, Goldberg, Michael
Publisher: Mcgraw-hill Education/stony Brook University
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Textbook Question
Chapter 22, Problem 14P
Compare and contrast the use of SNP genotyping: (i) in the positional cloning of Mendelian disease genes, (ii) in direct QTL mapping, and (iii) in GWAS.
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How might the Hardy Weinberg relationship be used to evaluate a new SNP genotyping technology using multiple individuals from a population? Group of answer choices
a)If genotypes match the reference genome, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs.
b)If observed phenotypes follow Hardy Weinberg, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs.
c)If genotypes and allele frequencies follow Hardy Weinberg, the technology is sound. Otherwise, the technology may have problems accurately calling SNPs.
d)None of the above
Select all that apply: A SNP (single nucleotide polymorphism) is similar to an STR (short tandem repeat) in that:
a) an individual can have many different copies of specific SNP or STR
b) they both cause diseases
c)they are sequences that have many possible variants
d) an individual has one copy of this region of the genome from each parent.
Using the information provided below, which of the individuals A and B have:
i) Genotypic change
ii) Phenotypic change
iii) Genotypic and phenotypic change
X is the partial CDNA sequence of the normal CFTR gene. Use this to determine which DNA sequence (A &B)
is the DNA extracted from a patient with and without disease.
X) ATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACATGGTATGACTCTCTTGGAGCAATAAACA
Met. A V IR Q F P WA V Q T W Y D S L GAI ..
A) ATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACAGGTATGACTCTCTTGGAGCAATAAACAA
Met.
B) ATGGCGGTCACTCGGCAATTTCCCTGGGCTGTACAAACTTGGTATGACTCTCTTGGAGCAATAAACA
Met.
Since this is a complementary DNA (CDNA) The nucleotide "T" can be directly replaced with U to get the mRNA
strand. Example: ATG is AUG, TCA is UCA etc
Second letter
G
UAU
UCU
c Phe UCc
UGU
UUC
U
UUA
UAC JTyr
UGCCYS
Ser
UCA
UCG
UAA Stop UGA Stop A
UAG Stop UGG Trp
UUG Leu
G.
CUU
CCU
CCC
Pro
CAU
CAC Hi.
CAA
CAGJ
CGU
CGC
CUC
CUA
Leu
CCA
Arg
CGA
Gin
CUG
CCG
CGG
AUU
ACU
ACC
ACA
AUG Met ACG
LAsn AGUser
AAC
AUC…
Chapter 22 Solutions
ND STONY BROOK UNIVERSITY LOOSELEAF GENETICS: FROM GENES TO GENOMES
Ch. 22 - Choose the best matching phrase in the right...Ch. 22 - Suppose you grew genetically identical dandelion...Ch. 22 - How can each of the following be used in...Ch. 22 - Two different groups of scientists studying a rare...Ch. 22 - Which of the following statements would be true of...Ch. 22 - Studies have indicated that for pairs of twins...Ch. 22 - Prob. 7PCh. 22 - Prob. 8PCh. 22 - Table 22.2 lists concordance values for MZ and DZ...Ch. 22 - Prob. 10P
Ch. 22 - Prob. 11PCh. 22 - Two alleles at one locus produce three distinct...Ch. 22 - In a certain plant, leaf size is determined by...Ch. 22 - Compare and contrast the use of SNP genotyping: i...Ch. 22 - Explain the similarities and differences between...Ch. 22 - In Fig. 22.14c, the fw2.2 causal gene was...Ch. 22 - Among the most prevalent pathologies that afflict...Ch. 22 - Human geneticists have found the Finnish...Ch. 22 - Canavan disease, caused by homozygosity for a...Ch. 22 - In GWAS analysis, because of the existence of LD...Ch. 22 - In Fig. 22.15: a. Why do some chromosomes in the...Ch. 22 - Consider the triangle diagram shown in Fig. 22.17....Ch. 22 - Prob. 23PCh. 22 - You conduct a Case/Control study comparing the...Ch. 22 - Prob. 25PCh. 22 - ALS amyotrophic lateral sclerosis is a rare, fatal...Ch. 22 - Through GWAS explorations, scientists have...Ch. 22 - In domesticated dogs, size has a high...Ch. 22 - Suppose a GWAS investigation found a particular LD...Ch. 22 - In 2008, Time magazine named as its invention of...
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