What is Life? A Guide to Biology with Physiology
What is Life? A Guide to Biology with Physiology
3rd Edition
ISBN: 9781464157745
Author: Jay Phelan
Publisher: W. H. Freeman
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Chapter 22, Problem 11MC
Summary Introduction

Introduction:

Digestion and absorption are two of the four stages of nutrient extraction.

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A 10 mg/Kg dose of a drug is given by intravenous injection to a 20 Kg dog. What would the volume of distribution be if the drug had been given orally and only 50% of the drug was absorbed (the concentration of drug at time = 0 is 0.1 mg/L)? Be sure to show your work.
After oral administration of 10mg of a drug, 50% is absorbed and 40% of the amount absorbed is metabolized by the first pass effect. The bioavailable dose of this drug is  ______. Make sure to provide units for your answer. Show your work.
A 10 mg/Kg dose of a drug is given by intravenous injection to a 20 Kg dog. What is the volume of distribution of the drug in liters if the plasma concentration is 0.1 mg/L (assume the drug is instantaneously distributed)? Be sure to show your work.
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