Products formed in the Sonogashira coupling reaction are to be determined. Concept introduction: Sonogashira coupling is the reaction in which an alkyne reacts with an alkenyl or an aryl halide in the presence of a mixture of catalytic palladium and copper ( I ) . It is a very good method to join an aromatic ring on alkyne.

Question

Want to see the full answer?

Answer 1

Question

Chapter 21, Problem 9PP

Interpretation Introduction

Interpretation:

Products formed in the Sonogashira coupling reaction are to be determined.

Concept introduction:

Sonogashira coupling is the reaction in which an alkyne reacts with an alkenyl or an aryl halide in the presence of a mixture of catalytic palladium and copper (I).

It is a very good method to join an aromatic ring on alkyne.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

(b) Suggest a reasonable biosynthesis for the naturally occurring alkaloid coniine (isolated from hemlock), starting from octanoic acid. Coniine

Account for the following:(i) Aniline does not give Friedel-Crafts reaction.(ii) Ethylamine is soluble in water whereas aniline is not.(iii) pKb of methylamine is less than that of aniline.

24.82 When the compound shown here is heated, ethene gas is evolved and a product with the formula C14H3O2 is formed. The 'H NMR and 13C NMR spectra of C14H8O2 are shown below. (There are two signals >150 ppm in the 13C NMR spectrum. Recall that the 13C NMR signal at 77 ppm is from the CDCI3 solvent.) (a) Draw the structure of C,14H3O2. (b) Draw the mechanism that accounts for its formation. (c) What is the main driving force that favors the products of this reaction? ? C14H3O2 C14H8O2 9. 8 7 6 4 3 2 1 250 200 150 100 50 Chemical shift (ppm) Chemical shift (ppm)