Chapter 21, Problem 24P

Interpretation Introduction

Interpretation:

The routes for the reactions that could form the desired products are to be provided.

Concept introduction:

The Heck Mizoroki reaction is a coupling reaction between an alkene and an alkenyl or aryl halide in the presence of a palladium catalyst and a base, usually an amine, at an elevated temperature. The active palladium catalyst involved in the reaction has only two ligands, so it is coordinatively unsaturated.

Ring closing metathesis is a process in organic chemistry by which various unsaturated rings are synthesized by the intramolecular metathesis of terminal alkenes. These reactions are catalyzed by metal complexes. Grubbs’ II reagent is a ruthenium-based carbene complex used as catalyst in ring closing metathesis. These catalysts can form di-substituted or tri-substituted alkenes.

The Suzuki Miyaura coupling is a palladium catalyzed reaction in which an alkenyl or aryl borate couple reacts with an alkenyl or aryl halide. In this reaction, the stereochemistry of reactants is retained in the products.