The effect on the structure of hemoglobin by the substitution of valine in place of glutamic acid is to be explained. Concept introduction: Hemoglobin is an oxygen carrying pigment made up of four heme groups that surrounds the globin group. Heme Group contains an iron atom which is responsible for the red color to the molecule. In sickle-cell disease, hemoglobin S is found. It is a type of anemia in which oxygen is in short supply and all the red blood cells become sickle-shaped. Hence, it is known as sickle-cell anemia. To determine: The effect on the structure of hemoglobin by the substitution of valine in place of glutamic acid.

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Chapter 21, Problem 93E

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Interpretation: The effect on the structure of hemoglobin by the substitution of valine in place of glutamic acid is to be explained.

Concept introduction: Hemoglobin is an oxygen carrying pigment made up of four heme groups that surrounds the globin group. Heme Group contains an iron atom which is responsible for the red color to the molecule. In sickle-cell disease, hemoglobin S is found. It is a type of anemia in which oxygen is in short supply and all the red blood cells become sickle-shaped. Hence, it is known as sickle-cell anemia.

To determine: The effect on the structure of hemoglobin by the substitution of valine in place of glutamic acid.

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