The nonlethal substitution for single glutamic acid in normal hemoglobin by glutamine is to be explained. Concept introduction: Amino acids are defined as organic compounds which contain amine ( − N H 2 ) and carboxyl ( − C O O H ) functional groups , along with a side chain (R group) attached to each amino acid. Hemoglobin is an oxygen transport metalloprotein, containing iron as a central metal atom. Glutamic acid and glutamine are amino acids produced in the muscles and are used in the biosynthesis of proteins. To determine: The explanation for a nonlethal substitution of glutamic acid by glutamine in hemoglobin.

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Chapter 21, Problem 94E

Interpretation Introduction

Interpretation: The nonlethal substitution for single glutamic acid in normal hemoglobin by glutamine is to be explained.

Concept introduction: Amino acids are defined as organic compounds which contain amine (−NH2) and carboxyl (−COOH) functional groups, along with a side chain (R group) attached to each amino acid. Hemoglobin is an oxygen transport metalloprotein, containing iron as a central metal atom. Glutamic acid and glutamine are amino acids produced in the muscles and are used in the biosynthesis of proteins.

To determine: The explanation for a nonlethal substitution of glutamic acid by glutamine in hemoglobin.

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