The major organic product(s) of the given reaction is to be predicted. Concept Introduction: Carboxylic acids in presence of the reagent NaH, THF followed by LDA yields the acid dianions in which the negative charge resides on both the oxygen atoms in the original carboxylic acid . However, the dianion formed has carbanionic character and it can potentially act as a nucleophile to create a new carbon-carbon single bond. The dianions formed when treated with primary or methyl halides the alkylation of acid dianions takes place. The new carbon-carbon single bond in these reactions is formed between the carbon atom bearing the halogen atom in the given alkyl halide and the alpha carbon atom in the given carboxylic acid.

Question

Want to see the full answer?

Answer 1

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 58DSP

Interpretation Introduction

Interpretation:

The major organic product(s) of the given reaction is to be predicted.

Concept Introduction:

Carboxylic acids in presence of the reagent NaH, THF followed by LDA yields the acid dianions in which the negative charge resides on both the oxygen atoms in the original carboxylic acid.

However, the dianion formed has carbanionic character and it can potentially act as a nucleophile to create a new carbon-carbon single bond.

The dianions formed when treated with primary or methyl halides the alkylation of acid dianions takes place.

The new carbon-carbon single bond in these reactions is formed between the carbon atom bearing the halogen atom in the given alkyl halide and the alpha carbon atom in the given carboxylic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Students have asked these similar questions

2. (15 points) Draw an appropriate mechanism for the following reaction. H N. H* + H₂O

Draw a tripeptide of your choosing at pH 7. Have the N-terminus on the left and the C-terminus on the right. Then: Draw a triangle around the α-carbons. Draw a box around the R-groups. Circle the atoms capable of hydrogen bonding. Highlight the atoms involved in the formation of the peptide bonds. What type of structure have you drawn? (primary, secondary, tertiary or quaternary protein structure). make sure its a tripeptide

Don't used hand raiting and don't used Ai solution

Answer 2

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 58DSP

Interpretation Introduction

Interpretation:

The major organic product(s) of the given reaction is to be predicted.

Concept Introduction:

Carboxylic acids in presence of the reagent NaH, THF followed by LDA yields the acid dianions in which the negative charge resides on both the oxygen atoms in the original carboxylic acid.

However, the dianion formed has carbanionic character and it can potentially act as a nucleophile to create a new carbon-carbon single bond.

The dianions formed when treated with primary or methyl halides the alkylation of acid dianions takes place.

The new carbon-carbon single bond in these reactions is formed between the carbon atom bearing the halogen atom in the given alkyl halide and the alpha carbon atom in the given carboxylic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 58DSP

Interpretation Introduction

Interpretation:

The major organic product(s) of the given reaction is to be predicted.

Concept Introduction:

Carboxylic acids in presence of the reagent NaH, THF followed by LDA yields the acid dianions in which the negative charge resides on both the oxygen atoms in the original carboxylic acid.

However, the dianion formed has carbanionic character and it can potentially act as a nucleophile to create a new carbon-carbon single bond.

The dianions formed when treated with primary or methyl halides the alkylation of acid dianions takes place.

The new carbon-carbon single bond in these reactions is formed between the carbon atom bearing the halogen atom in the given alkyl halide and the alpha carbon atom in the given carboxylic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 58DSP

Interpretation Introduction