It is to be shown how to carry out the given synthesis. Concept introduction: When amines are treated with acyl chloride in the presence of a weak base like pyridine, the amine group is protected in the form of acetamide derivative. For deprotection, simply an acidic condition is required. Potassium dichromate ( K 2 Cr 2 O 7 ) is a strong oxidizing agent and oxidizes primary alcohol to a corresponding carboxylic acid .

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Answer 1

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 21.34P

Interpretation Introduction

Interpretation:

It is to be shown how to carry out the given synthesis.

Concept introduction:

When amines are treated with acyl chloride in the presence of a weak base like pyridine, the amine group is protected in the form of acetamide derivative. For deprotection, simply an acidic condition is required. Potassium dichromate (K2Cr2O7) is a strong oxidizing agent and oxidizes primary alcohol to a corresponding carboxylic acid.

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3. Propose a synthesis for the following transformation. Do not draw an arrow-pushing mechanism below, but make sure to draw the product of each proposed step (3 points). + En CN CN

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Answer 2

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Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 21.34P

Interpretation Introduction

Interpretation:

It is to be shown how to carry out the given synthesis.

Concept introduction:

When amines are treated with acyl chloride in the presence of a weak base like pyridine, the amine group is protected in the form of acetamide derivative. For deprotection, simply an acidic condition is required. Potassium dichromate (K2Cr2O7) is a strong oxidizing agent and oxidizes primary alcohol to a corresponding carboxylic acid.

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Answer 3

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 21.34P

Interpretation Introduction

Interpretation:

It is to be shown how to carry out the given synthesis.

Concept introduction:

When amines are treated with acyl chloride in the presence of a weak base like pyridine, the amine group is protected in the form of acetamide derivative. For deprotection, simply an acidic condition is required. Potassium dichromate (K2Cr2O7) is a strong oxidizing agent and oxidizes primary alcohol to a corresponding carboxylic acid.

Expert Solution & Answer

Want to see the full answer?

Check out a sample textbook solution

See solution

Answer 4

Question

Definition Definition Class of organic compounds that contain a carboxyl group ( - COOH ) and has a general formula R - COOH or R - CO 2 H , where R refers to the alkyl, alkenyl, aryl, or other groups. They can undergo different chemical reactions, such as acid-base reactions, esterification, and oxidation. These are essential components of living organisms, playing important roles in metabolic processes, signaling, and as pharmaceuticals.

Chapter 21, Problem 21.34P

Interpretation Introduction