Chapter 20.5, Problem 11CC

(a)

Interpretation Introduction

Interpretation:

The target molecule transformation should be drawn and identified for the given corresponding starting molecules by using selective reagents.

Concept introduction:

Acid Catalyzed Hydration Reaction: The reaction involves breaking of π-bonds between carbon-carbon multiple bonds and addition of alcohol to more substituted position of carbon in the molecule.

Elimination Reaction: It is just reverse reaction of addition where substituent from the given molecule is removed via E1 (the reaction depends only on the substrate involved in the reaction) or E2 (the reaction depends on both of the substituents in the reaction) mechanism.

Sodium amide ( ${\text{NaNH}}_{\text{2}}$): The strong base of ${\text{NaNH}}_{\text{2}}$ will deprotonate alkynes, alcohols and other organic functional groups with acidic protons such as esters and ketones. It is also a very strong nucleophile. It is a strong base and excellent nucleophile. It’s used deprotonated of weak acids and also for elimination reaction.

Grignard reagent: This is a organometallic reaction in different alkyl, aryl-magnesium halides add to a carbonyl group in an aldehyde and ketone. This reaction is an important for the conversion of carbon-carbon single ( $\text{-C-C-}$) bond. Moreover the addition of a reagent to an aster, lactone gives a tertiary alcohol in which two alkyl groups are the same and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone.

Nucleophilic Substitution reaction: electron rich nucleophiles attack the positive or partially positive charge of an atom and replace a leaving group is called Nucleophilic Substitution reaction.

LAH Reduction: The saturated/unsaturated aldehyde and ketones in the presence of sodium metal in LAH and carbonyl compound produced saturated alcohols. The keto group involves in the reduction process of LAH, this end up reducing to give the alcohols.

(b)

Interpretation Introduction

Interpretation:

The target molecule transformation should be drawn and identified for the given corresponding starting molecules by using selective reagents.

Concept introduction:

Acid Catalyzed Hydration Reaction: The reaction involves breaking of π-bonds between carbon-carbon multiple bonds and addition of alcohol to more substituted position of carbon in the molecule.

Elimination Reaction: It is just reverse reaction of addition where substituent from the given molecule is removed via E1 (the reaction depends only on the substrate involved in the reaction) or E2 (the reaction depends on both of the substituents in the reaction) mechanism.

Sodium amide ( ${\text{NaNH}}_{\text{2}}$): The strong base of ${\text{NaNH}}_{\text{2}}$ will deprotonate alkynes, alcohols and other organic functional groups with acidic protons such as esters and ketones. It is also a very strong nucleophile. It is a strong base and excellent nucleophile. It’s used deprotonated of weak acids and also for elimination reaction.

Grignard reagent: This is a organometallic reaction in different alkyl, aryl-magnesium halides add to a carbonyl group in an aldehyde and ketone. This reaction is an important for the conversion of carbon-carbon single ( $\text{-C-C-}$) bond. Moreover the addition of a reagent to an aster, lactone gives a tertiary alcohol in which two alkyl groups are the same and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone.

Nucleophilic Substitution reaction: electron rich nucleophiles attack the positive or partially positive charge of an atom and replace a leaving group is called Nucleophilic Substitution reaction.

LAH Reduction: The saturated/unsaturated aldehyde and ketones in the presence of sodium metal in LAH and carbonyl compound produced saturated alcohols. The keto group involves in the reduction process of LAH, this end up reducing to give the alcohols.

(c)

Interpretation Introduction

Interpretation:

The target molecule transformation should be drawn and identified for the given corresponding starting molecules by using selective reagents.

Concept introduction:

Acid Catalyzed Hydration Reaction: The reaction involves breaking of π-bonds between carbon-carbon multiple bonds and addition of alcohol to more substituted position of carbon in the molecule.

Elimination Reaction: It is just reverse reaction of addition where substituent from the given molecule is removed via E1 (the reaction depends only on the substrate involved in the reaction) or E2 (the reaction depends on both of the substituents in the reaction) mechanism.

Sodium amide ( ${\text{NaNH}}_{\text{2}}$): The strong base of ${\text{NaNH}}_{\text{2}}$ will deprotonate alkynes, alcohols and other organic functional groups with acidic protons such as esters and ketones. It is also a very strong nucleophile. It is a strong base and excellent nucleophile. It’s used deprotonated of weak acids and also for elimination reaction.

Grignard reagent: This is a organometallic reaction in different alkyl, aryl-magnesium halides add to a carbonyl group in an aldehyde and ketone. This reaction is an important for the conversion of carbon-carbon single ( $\text{-C-C-}$) bond. Moreover the addition of a reagent to an aster, lactone gives a tertiary alcohol in which two alkyl groups are the same and the addition of a Grignard reagent to a nitrile produces an unsymmetrical ketone.

Nucleophilic Substitution reaction: electron rich nucleophiles attack the positive or partially positive charge of an atom and replace a leaving group is called Nucleophilic Substitution reaction.

LAH Reduction: The saturated/unsaturated aldehyde and ketones in the presence of sodium metal in LAH and carbonyl compound produced saturated alcohols. The keto group involves in the reduction process of LAH, this end up reducing to give the alcohols.