Microbiology: An Introduction
12th Edition
ISBN: 9780321929150
Author: Gerard J. Tortora, Berdell R. Funke, Christine L. Case
Publisher: PEARSON
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Textbook Question
Chapter 20, Problem 8R
The −OH is missing from carbon 39 in ddI. How does ddI inhibit DNA synthesis?
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Chapter 20 Solutions
Microbiology: An Introduction
Ch. 20 - DRAW IT Show where the following antibiotics work:...Ch. 20 - List and explain five criteria used to identify an...Ch. 20 - What similar problems are encountered with...Ch. 20 - Define drug resistance. How is it produced? What...Ch. 20 - List the advantages of using two chemotherapeutic...Ch. 20 - Why does a cell die from the following...Ch. 20 - How does each of the following inhibit...Ch. 20 - The OH is missing from carbon 39 in ddI. How does...Ch. 20 - Compare the method of action of the following...Ch. 20 - NAME IT This microorganism is not susceptible to...
Ch. 20 - Which of the following pairs is mismatched? a....Ch. 20 - Prob. 2MCQCh. 20 - Prob. 3MCQCh. 20 - An antimicrobial agent should meet all of the...Ch. 20 - The most selective antimicrobial activity would be...Ch. 20 - Prob. 6MCQCh. 20 - Which of the following will not affect eukaryotic...Ch. 20 - Cell membrane damage causes death because a. the...Ch. 20 - A drug that intercalates into DNA has the...Ch. 20 - Chloramphenicol binds to the 50S portion of a...Ch. 20 - Prob. 1ACh. 20 - Why is idoxuridine effective if host cells also...Ch. 20 - Some bacteria become resistant to tetracycline...Ch. 20 - The following data were obtained from a...Ch. 20 - Prob. 5ACh. 20 - The following results were obtained from a broth...Ch. 20 - Vancomycin-resistant Enterococcus faecalis was...Ch. 20 - Prob. 2CAECh. 20 - Prob. 3CAE
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- Explain why methotrexate inhibits the synthesis of histidine and methionine.arrow_forwardMethyl iodide (CH31) can be used to modify DNA in solution. It takes the following mechanism for this reaction: Step 1. (slow) CHз снз* + г Step 2. (fast) DNA + CH3* > DNA-CH3* Which of the following is true about this reaction and its mechanism? O a. lodide ion (I ") is an intermediate in the reaction. Ob.CH3* is a catalyst of this reaction. O. The activation energy of Step 1 must be lower than the activation energy of Step 2. d. The overall reaction order of the reaction predicted by this mechanism is 1st order. By increasing temperature, the rate constant of Step 1 will increase but the rate constant of Step 2 will е. decrease.arrow_forwardHow does a disorder in mitochondria lead to diabetes? What kind of diabetes is it?And Which two co-factors are able to transfer methyl groups? Which one is more preferredfor methyl and why?arrow_forward
- What is the purpose of dideoxyribonucleoside triphosphates, or ddNTPs?arrow_forward5-Bromouridine is known to induce mutations in DNA. One of the characteristics of this compound is that the enol form is favored relative to the keto form. Draw the keto- and the eno- tautomers of the base. Determine (and draw) which base (A, T, G, or C) would most likely interact with each of the two forms by base-pair.arrow_forward(a) Draw the structure of the high-energy nucleoside triphosphate GTP. (b) Draw the structure of the hydrolysis product formed when one phosphate is removed.arrow_forward
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