Biochemistry
6th Edition
ISBN: 9781305577206
Author: Reginald H. Garrett, Charles M. Grisham
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Question
Chapter 20, Problem 2P
Interpretation Introduction
To propose:
For the reaction of glyceraldehyde3 phosphate dehydrogenase, the
Introduction:
The enzyme glyceraldehyde3 phosphate dehydrogenase is essential in gluconeogenesis and glycolysis and their cycles are seen in the cytoplasm. This enzyme helps to catalyze the conversion reaction that is reversible of glyceraldehyde3 phosphate and also phosphate that is inorganic into 1, 3-BPG (1,3-bisphosphoglycerate) in 3 steps of reaction.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
7.
Breakdown rxn of GIUCOSE. What is the Cleland diagram for the reaction glyceraldehyde 3-phosphate to 1,3
diphosphoglycerate? Based this on the following steps:
a. Glyceraldehyde3-phosphate binds to the enzyme,E
b. NAD binds to the enzyme E then is reduced to NADH
c. NADH leaves the enzyme
d. Phosphate binds to the enzyme and attacks the glycerate phosphate
attached to the enzyme
e. 1,3-disphosphoglycerate leaves the enzyme as the final procut
The Payoff Phase of Glycolysis in Skeletal Muscle
In the skeletal muscle, in anaerobic conditions, glyceraldehyde 3-
phosphate is converted into pyruvate during the payoff phase of
glycolysis; and this pyruvate is reduced into lactate during lactic
fermentation.
1-Write the 11 balanced biochemical equations corresponding to all|
the reaction steps leading to the conversion of glyceraldehyde-3-
phosphate into lactate through glycolysis followed by lactic
fermentation.
2-Write the net equation of the whole transformation process (i.e.
with glyceraldehyde-3-phosphate as the starting substrate; and lactate
as the end product).
Knowledge Booster
Similar questions
- Having trouble with thisarrow_forwardgeneration of one less FADH2 molecule. Part C B-oxidation dealls with only saturated fatty acids, but many fatty acids in natural lipids are unsaturated, meaning they contain one or more double bonds. Considering the fatty acid below, calculate the energy yield of its complete oxidation. OH Express your answer using three significant figures. ▸ View Available Hint(s) ΑΣΦ + 0 ? Submit ATParrow_forward27. Working at cross-purposes . Write a balanced equation showing the effect of simultaneous activation of glycogen phosphorylase and glycogen synthase. Include the reactions catalyzed by phosphoglucomutase and UDP-glucose pyrophosphorylase.arrow_forward
- 6-25 substrate-band enzyme concentrations. The the turnover number is equal to umax- b) V=Umax •57(Km+S) anstont For an enzyme that displays Michaelis-Menten kinetics, what is the reaction velocity, V (as a percentage of Vmax), observed at the following values? a) [S] = KM C) d) e) [S] = 0.5KM [S] = = 0.1KM [S] = 2KM [S] = 10KM w reactores -maximumrate of reaction boteles conc. Would you expect the structure of a competitive inhibitor of a given enzyme to be similar to that of its substrate?arrow_forwardThe conversion of glucose-6-phosphate to fructose-6-phosphate in the glycolytic pathway (Choose all that apply) O positions a carbonyl group on carbon 2 of fructose-1-phosphate O positions an amino group NH2 on carbon 3 of fructose-1-phosphate O positions a carbonyl group on carbon 3 of fructose-1-phosphate O is an aldose-keto isomerization O positions a primary alcohol function at carbon C-1 that facilitates phosphorylation of fructose-6-phosphate O is a keto-aldose isomerization O positions an amino group NH2 on carbon 2 of fructose-1-phosphatearrow_forwardNeed help, please.arrow_forward
- H. OH co co2 но H co, 1-isopropylmalate 2-isopropylmalate Biosynthesis of leucine involves conversion of 1-isopropyimalate to 2-isopropylmalate (see above). This proceeds in four steps under basic enzymic catalysis via an isolable compound produced in step 2. Write a detailed mechanism for this conversion. Then, draw the intermediate compound) produced in step 2. • You do not have to consider stereochemistry. • Draw uninvolved carboxyl groups in the anionic state, and enolates as carbanions. When needed, abbreviate CoenzymeA-S- as CH3S- In your drawing. aalearrow_forwardExtending the Mechanism of Methylmalonyl-CoA Mutase to Similar Reactions Based on the mechanism for the methylmalonyl-CoA mutase (see problem 14), write reasonable mechanisms for the following reactions shown.arrow_forwardUnderstanding the Mechanism of the 3-ketosphinganine Synthase Reaction Write a reasonable mechanism for the 3-ketosphinganine synthase reaction, remembering that it is a pyridoxal phosphate-dependent reaction.arrow_forward
- Understanding the Oxidation of Glucose and Its Products in the TCA Cycle Glycolysis, the pyruvate dehydrogenase reaction, and the TCA cycle result in complete oxidation of a molecule of glucose to CO2. Review the calculation of oxidation numbers for individual atoms in any molecule, and then calculate the oxidation numbers of the carbons of glucose, pyruvate, the acetyl carbons of acetyl-CoA. and the metabolites of the TCA cycle to convince yourself that complete oxidation of glucose involves removal of 24 electrons and that each acetyl-CoA through the TCA cycle gives up 8 electrons.arrow_forwardThe Effect of lodoacetic Acid on the Glyceraldehyde-3-P Dehydrogenase Reaction (Integrates with Chapters 4 and 14.) How might iodoacetic acid affect the glyceraldehydes-3-phosphate dehydrogenase reaction in glycolysis? Justify your answer.arrow_forwardInhibition of Purine and Pyrimidine Metabolism by Pharmacological Agents Indicate which reactions of purine or pyrimidine metabolism are affected by the inhibitors (a) azaserine, (b) methotrexate, (c) sulfonamides, (d) allopurinol, and (e) 5-fluorouracil.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning