Human Anatomy & Physiology
1st Edition
ISBN: 9780805382952
Author: Erin C. Amerman
Publisher: PEARSON
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Textbook Question
Chapter 20, Problem 15CYR
Fill in the blanks: Class I MHC molecules display ___________antigens and activate _________cells. Class II MHC molecules display ___________antigens and activate ____________cells.
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Write T if the statement is correct; write F if the statement is not correct.
Antigen fragments that bind to MHC class I molecules are typically in endosomes. " "
TAP1 and TAP2 are present on the plasma membrane of APCs. " "
Proteasomes process antigens within the endoplasmic reticulum. " "
Newly synthesized MHC class I molecules can be found within endosomes. " "
Newly synthesized MHC class I α chains assemble in the ER with calnexin. " "
Write T if the statement is correct; write F if the statement is not correct.
Interferons enhance antigen presentation. " "
Peptides that bind to MHC class II molecules are longer than those that bind MHC class I molecules. " "
MHC molecules that lack a bound peptide is unstable. " "
MHC class I:peptide:TCRcomplexes and MHC class II:peptide:TCR complex shows very similar orientation. " "
The Golgi apparatus is part of the endomembrane system. " "
Which statement is true?
Class I MHCs display exogenous antigen and are present on all nucleated cells.
Class II MHCs display exogenous antigen and are present on antigen presenting cells.
Class I MCHs display endogenous antigen and are present on antigen presenting cells.
Class II MCHs display endogenous antigen and are present on all nucleated cells.
Chapter 20 Solutions
Human Anatomy & Physiology
Ch. 20.1 - What are the main functions of the lymphatic...Ch. 20.1 - 2. How do lymphatic capillaries differ from blood...Ch. 20.1 - What is the pathway of lymph flow from the right...Ch. 20.1 - 4. What main cell types are located in lymphoid...Ch. 20.1 - List the main functions of MALT, lymph nodes, the...Ch. 20.2 - 1. How do innate immunity and adaptive immunity...Ch. 20.2 - 2. What are the three lines of defense?
Ch. 20.2 - What are the bodys main surface barriers, and how...Ch. 20.2 - Prob. 4QCCh. 20.2 - How are the immune system and lymphatic system...
Ch. 20.3 - Match the following cell types with their correct...Ch. 20.3 - Which of the cells in question 1 do not directly...Ch. 20.3 - What is the complement system, and what are its...Ch. 20.3 - In what two ways is the complement system...Ch. 20.3 - 5. What are the main cytokines of innate...Ch. 20.3 - What are the four cardinal signs of inflammation?Ch. 20.3 - 7. What are inflammatory mediators, and what do...Ch. 20.3 - Explain the role of phagocytes in the inflammatory...Ch. 20.3 - What causes the elevated temperature and common...Ch. 20.3 - Prob. 10QCCh. 20.4 - 1. What are MHC molecules?
Ch. 20.4 - 2. How do class I and class II MHC molecules...Ch. 20.4 - How are T cells activated?Ch. 20.4 - Prob. 4QCCh. 20.4 - What are the main functions of TC cells?Ch. 20.4 - Prob. 6QCCh. 20.4 - Prob. 7QCCh. 20.5 - 1. How is a B cell activated?
Ch. 20.5 - Prob. 2QCCh. 20.5 - What are the five classes of antibody, and how do...Ch. 20.5 - 4. List the five main functions of antibodies.
Ch. 20.5 - How do the primary and secondary immune responses...Ch. 20.5 - 6. What is the purpose of a vaccination, and what...Ch. 20.5 - 7. How do active immunity and passive immunity...Ch. 20.6 - How do innate immunity and adaptive immunity work...Ch. 20.6 - Walk through the basic steps of the immune...Ch. 20.6 - How does the immune system survey the body for...Ch. 20.6 - Walk through the steps of the immune response to...Ch. 20.6 - Prob. 5QCCh. 20.6 - 6. How do cancer cells escape the immune response...Ch. 20.7 - Define the four types of hypersensitivity...Ch. 20.7 - Explain how type IV hypersensitivity differs from...Ch. 20.7 - How do primary and secondary immunodeficiency...Ch. 20.7 - Prob. 4QCCh. 20.7 - What is an autoimmune disorder? What produces the...Ch. 20.7 - 6. What are the potential causes of autoimmune...Ch. 20 - 1. Which of the following is not a function of the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Fill in the blanks: The lymphoid organ that...Ch. 20 - Fill in the blanks: Nonspecific immunity is also...Ch. 20 -
5. Which of the following make up the body’s...Ch. 20 - Which of the following does not describe the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Which of the following functions is/are performed...Ch. 20 - Prob. 9CYRCh. 20 - 10. When naïve B cells are activated, they...Ch. 20 - 11. Match the following antibodies with the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Prob. 13CYRCh. 20 - On which type(s) of cells are class I MHC...Ch. 20 - Fill in the blanks: Class I MHC molecules display...Ch. 20 - 16. Which of the following is not a role of TH...Ch. 20 - 17. Mark the following statements as true or...Ch. 20 - 18. Type I hypersensitivity is due to release of...Ch. 20 - Prob. 19CYRCh. 20 - Prob. 20CYRCh. 20 - Prob. 1CYUCh. 20 - Complement proteins are crucial for stimulating...Ch. 20 - 3. Terrence has severe asthma and allergies, and...Ch. 20 - Your friend tests her snake-wrangling skills on an...Ch. 20 - 2. Carla presents to her physician with a...Ch. 20 - 3. Mr. White has been diagnosed with febrile...Ch. 20 - Mr. White developed neutropenia as a consequence...Ch. 20 - 5. The chemotherapeutic drugs Mr. White is taking...
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- Figure 42.11 Which of the following statements about T cells is false? Helper T cells release cytokines while cytotoxic T cells kill the infected cell. Helper T cells are CD4+, while cytotoxic T cells are CD8+. MHC II is a receptor found on most body cells, while MHC I is a receptor found on immune cells only. The T cell receptor is found on both CD4+ and CD8+ T cells.arrow_forwardIndicate whether each of the cell components or processes given is involved the processing and presentation of exogenous antigens, endogenous antigens, or both. (Assume n cross-presentation here.) Exognenous Both Possible answers proteasomes MHC class II molecules No Answers Chosen No Answers Chosen phagocytosis or endocytosis invariant chains calnexin tapasin Endogenous No Answers Chosen vesicular transport from RER to Golgi lysosomal hydrolases TAP1 and TAP2 proteins MHC class I moleculesarrow_forward__________________________________________________ cells can help prevent autoimmune diseases. The antigen receptor on a B cell is essentially a membrane-bound ____________________________. If a cell of yours lacks MHCs, ______________________________________ (specific kind of cell) might cause its death _________________________________ is the name of the migration activity by a neutrophil, e.g., when it is physiologically driven to move toward molecules at an area of injury. Its temporary binding and unbinding to sticky endothelial cell adhesion molecules on their way is called _______________________________________. When it enters the injured or infected tissue space from the capillary this is called ____________________________________. When identical plasma cells start being made, in great abundance, from a single specific immune cell, the originally chosen immune cell has undergone ______________________ - ______________________________________. What are a few things discussed…arrow_forward
- MHC class II proteins: A. present exogenous antigen to the immune system B. both are found on antigen presenting cells and present exogenous C. antigen to the immune system are found on antigen presenting cellsarrow_forwardClass II MHC proteins display what kind of antigens? What class of T cell recognizes antigens bound to class II MHC? What types of cells display these proteins?arrow_forwardIdentify the cells that display MHC class I and MHC class IIproteins on their surfacesarrow_forward
- Why would a virus that can interfere with a host cell’s production of MHC class I molecules be at an advantage?arrow_forwardWhich of the following statements is TRUE about NK cells? Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a b C d NK cells mediate the rejection of MHCa bone marrow transplants into MHCª x MHCb F1 mice NK cells mediate the rejection of MHCa x MHC F1 bone marrow transplants into MHCa mice Detection of type I IFN (IFNa or IFNB) by NK cells decreases their cytotoxic capacity Down-regulation of MHC I molecules on target cells decreases NK cytotoxicityarrow_forwardExplain what is happening in this picture.arrow_forward
- Cancer cells often underexpress MHC class 1 molecules. Due to these characteristics, they may be the target of: B cells Eosinophils Neutrophils NK cells OMacrophagesarrow_forwardThe diagram shows a pathogen (in red) that is present in different cellular compartments of each of the cell types shown. In each case, a specific T cell subset will recognize peptides of that pathogen presented on MHC molecules on the surface of the cell, and will execute its effector function. From the list below, match the appropriate T cell effector response to the cell type and location of the pathogen. CD4 T cell killing of target cell CD8 T cell killing of target cell CD4 T cell activation of target cell’s antibody production CD8 T cell activation of target cell’s antibody production CD4 T cell activation of target cell’s ability to kill intracellular pathogen CD8 T cell activation of target cell’s ability to kill intracellular pathogenarrow_forwardThe cytokine that activates macrophages, inhibits viral replication, and increases MHC Class I expression is interferon. True Falsearrow_forward
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