Human Anatomy & Physiology
1st Edition
ISBN: 9780805382952
Author: Erin C. Amerman
Publisher: PEARSON
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Chapter 20, Problem 20CYR
Summary Introduction
Introduction:
Autoimmunity is the condition when an immune response is generated against self-antigens present in the body. This results in the autoimmune disorder, which may be localized or systemic, depending upon the number of organs affected. Such disorders result in type II, III or IV hypersensitivity and result in damage to tissues and organs. There are several conditions that can result in the development of autoimmunity.
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Which of the following statements are true for antigen presentation.
a.
Antigen presentation means that other cells attach the pathogen first and present it to T cells.
b.
Antigen-presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor to B cells
c.
Antigen presenting cells display protein fragments, resulting from the digestion of the pathogen, in complex with MHC receptor on their surface.
d.
Antigen-presenting cells are phagocytic cells
e.
Antigen presentation is required for T cell activation
f.
Cytokines released by macrophages are required for T cell activation
g.
T cell receptors recognize the MHC receptors in complex with antigen fragments displayed by antigen-presenting cells.
h.
Phagocytic cells are involved in innate immunity. Therefore they have no role in T-cell activation
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b.
macropinocytosis of bacteria or viruses.
c. uptake of viruses using Toll-like receptor TLR9.
d.
cross-presentation from the MHC class II pathway to the MHC class I pathway.
Oe. cross-presentation from incoming infected dendritic cells to healthy resident dendritic cells in secondary
lymphoid tissue.
Of. delivery of viral peptides from cytosol to endoplasmic reticulum during viral infection.
In organ transplantation, minor histocompatibility antigens
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Chapter 20 Solutions
Human Anatomy & Physiology
Ch. 20.1 - What are the main functions of the lymphatic...Ch. 20.1 - 2. How do lymphatic capillaries differ from blood...Ch. 20.1 - What is the pathway of lymph flow from the right...Ch. 20.1 - 4. What main cell types are located in lymphoid...Ch. 20.1 - List the main functions of MALT, lymph nodes, the...Ch. 20.2 - 1. How do innate immunity and adaptive immunity...Ch. 20.2 - 2. What are the three lines of defense?
Ch. 20.2 - What are the bodys main surface barriers, and how...Ch. 20.2 - Prob. 4QCCh. 20.2 - How are the immune system and lymphatic system...
Ch. 20.3 - Match the following cell types with their correct...Ch. 20.3 - Which of the cells in question 1 do not directly...Ch. 20.3 - What is the complement system, and what are its...Ch. 20.3 - In what two ways is the complement system...Ch. 20.3 - 5. What are the main cytokines of innate...Ch. 20.3 - What are the four cardinal signs of inflammation?Ch. 20.3 - 7. What are inflammatory mediators, and what do...Ch. 20.3 - Explain the role of phagocytes in the inflammatory...Ch. 20.3 - What causes the elevated temperature and common...Ch. 20.3 - Prob. 10QCCh. 20.4 - 1. What are MHC molecules?
Ch. 20.4 - 2. How do class I and class II MHC molecules...Ch. 20.4 - How are T cells activated?Ch. 20.4 - Prob. 4QCCh. 20.4 - What are the main functions of TC cells?Ch. 20.4 - Prob. 6QCCh. 20.4 - Prob. 7QCCh. 20.5 - 1. How is a B cell activated?
Ch. 20.5 - Prob. 2QCCh. 20.5 - What are the five classes of antibody, and how do...Ch. 20.5 - 4. List the five main functions of antibodies.
Ch. 20.5 - How do the primary and secondary immune responses...Ch. 20.5 - 6. What is the purpose of a vaccination, and what...Ch. 20.5 - 7. How do active immunity and passive immunity...Ch. 20.6 - How do innate immunity and adaptive immunity work...Ch. 20.6 - Walk through the basic steps of the immune...Ch. 20.6 - How does the immune system survey the body for...Ch. 20.6 - Walk through the steps of the immune response to...Ch. 20.6 - Prob. 5QCCh. 20.6 - 6. How do cancer cells escape the immune response...Ch. 20.7 - Define the four types of hypersensitivity...Ch. 20.7 - Explain how type IV hypersensitivity differs from...Ch. 20.7 - How do primary and secondary immunodeficiency...Ch. 20.7 - Prob. 4QCCh. 20.7 - What is an autoimmune disorder? What produces the...Ch. 20.7 - 6. What are the potential causes of autoimmune...Ch. 20 - 1. Which of the following is not a function of the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Fill in the blanks: The lymphoid organ that...Ch. 20 - Fill in the blanks: Nonspecific immunity is also...Ch. 20 -
5. Which of the following make up the body’s...Ch. 20 - Which of the following does not describe the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Which of the following functions is/are performed...Ch. 20 - Prob. 9CYRCh. 20 - 10. When naïve B cells are activated, they...Ch. 20 - 11. Match the following antibodies with the...Ch. 20 - Mark the following statements as true or false. If...Ch. 20 - Prob. 13CYRCh. 20 - On which type(s) of cells are class I MHC...Ch. 20 - Fill in the blanks: Class I MHC molecules display...Ch. 20 - 16. Which of the following is not a role of TH...Ch. 20 - 17. Mark the following statements as true or...Ch. 20 - 18. Type I hypersensitivity is due to release of...Ch. 20 - Prob. 19CYRCh. 20 - Prob. 20CYRCh. 20 - Prob. 1CYUCh. 20 - Complement proteins are crucial for stimulating...Ch. 20 - 3. Terrence has severe asthma and allergies, and...Ch. 20 - Your friend tests her snake-wrangling skills on an...Ch. 20 - 2. Carla presents to her physician with a...Ch. 20 - 3. Mr. White has been diagnosed with febrile...Ch. 20 - Mr. White developed neutropenia as a consequence...Ch. 20 - 5. The chemotherapeutic drugs Mr. White is taking...
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Similar questions
- A number of minor cancerous cells and infected viruses, such as Epstein Barr (EBV), are able to go undetected by cytotoxic T cell degradation by what possible mechanism? a. the production of normal class I MHC molecule b. helper T cell activation c. the deactivation of the complement system d. tumor antigen expression e. the production of the class II major histocompatability (MHC) moledulearrow_forwardWhich of the following statements regarding T cells activated by specific antigen is incorrect? a. They receive co-stimulatory signals through CD28. b. They suppress expression of sphingosine 1-phosphate (SIP). c. They take several days before differentiating into effector T cells. d. They cease to secrete and respond to interleukin-2 (IL-2). e. They begin to express CTLA4, which serves to limit T-cell proliferation.arrow_forwardWhich of the following explains why dendritic cells, but not macrophages or B cells, contribute to the activation of naive T cells? a. Macrophages and B cells do not express MHC class II molecules until they are activated. b. Dendritic cells upregulate B7 after engaging innate immunity receptors at sites of infection. c. Dendritic cells express higher levels of CTLA4. d. Macrophages and B cells do not process antigen. e. Dendritic cells use Toll-like receptors to hold antigen in place for extended periods of time.arrow_forward
- Antibodies can have multiple mechanisms of action. The main mechanism is "flagging" a foreign body for phagocytosis and degradation. Another mechanism is... Select one: a. Binding of the Fc domain to T cells for cooperative antigen recognition and destruction. b. Altering the local pH by the formation of carbamate upon reaction with CO2 to denature protein antigens. c. Binding of the variable region to multiple different/distinct sites on the antigen. d. None of these. e. Binding of the antigen in regions essential for its function.arrow_forwardExplain why each choice (a-d) is correct or incorrect. In order for an antigen to activate or sensitize a T helper cell, the antigen must be a. coated with antibodies b. displayed on the surface of an APC along with MHC antigens c. displayed on the surface of another T cell with IgD antibodies d. partly digested by a natural killer cellarrow_forwardWhich of the following best describes the impacts of antigenic variation? Mark all that apply. A. requires clonal selection of B cells B. causes a primary immune response C. involves T-independent immune responses D. memory cells are stimulated by the antigen variantsarrow_forward
- Which of the following is false about HLA class I molecules? A. They are encoded by multiple and highly polymorphic genes. B. They consist of alpha and beta chains. C. They possess beta-2 microglobulin. D. They present foreign antigens to cytotoxic T cells. E. none of the abovearrow_forwardWhich of the following statements does not describe tolerogens accurately? Select one: A. They can be the same molecules as immunogens. B. They lead immune cells to become unresponsive. C. They can be foreign antigens. D. They affect B cells but not T cells. E. The can be presented by antigen- presenting cells.arrow_forwardWhich of the following best defines MHC restriction? Select one: a. The TCR recognizes a particular epitope in the context of a specific MHC molecule. b. Any given MHC molecule is able to bind a wide variety of epitopes. C. The TCR recognizes only the MHC molecule. Od. The TCR recognizes the epitope bound to any MHC molecule having the correct motif. Oe. A TCR may bind to either an MHC Class I or MHC Class II molecule along with the bound epitope.arrow_forward
- CHAPTER 20 The Lymphatic System and Immunity Matching SECTION 3 Revie w Match each lettered term with the most closely related description. a. opsonization 1 b. helper T cells Two parallel pairs of polypeptide chains Found on helper T cells C. antibody d. class II MHC 3 Active and passive 4 Transfer of antibodies e. costimulation Attacked by HIV f. IgM 6 Enhances phagocytosis g. class I MHC h. IgG 7 MHC proteins present in the plasma membranes of all nucleated cells i. passive immunity j. anaphylaxis 8 Differentiate into memory and plasma cells 9 MHC proteins present in the plasma membranes of all APCS and lymphocytes 9 k. CD4 markers 10 I. acquired immunity 10 Antibodies used to determine blood type 11 m. B lymphocytes 11 Secondary binding process required for T cell activation 12 12 Accounts for 80 percent of all immunoglobulins 13 13 Circulating allergen stimulates mast cells throughout body Match each lettered term with thearrow_forwardWhich of the following pairs is mismatched? a. plasma cell: mediation of phagocytosis and killing of microorganisms in the plasma b. megakaryocyte: formation of platelets c. dendritic cell: activation of adaptive immune responses d. natural killer cell: develops from a common lymphoid progenitor e. neutrophil: formation of pus f. regulatory T cell: inhibition of T-cell activity.arrow_forwardMHC restriction is best described as a. elimination of thymocytes bearing T-cell receptors that are unable to interact with self-MHC molecules b. preferential survival and proliferation of thymocyes that survive negative selection c. T-cell recognition of a peptide antigen only when it is bound to a particular form of MHC molecule d. a state of non-responsiveness to a peptide antigen e. a condition in which either MHC class I or class II molecules are not expressed on cells.arrow_forward
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