Targeted delivery of a "death package" 1 MHC class I 2 3 Virus molęcule Viral genome -Natural killer cell Virus infects a cell. Virus prevents its host cell from displaying MHC class I molecules. Without these, the cell cannot be a target of Tc cells. Natural killer (NK) cell initiates apoptosis in the stressed "self" cell that lacks MHC class I molecules. Infected cell undergoes apoptosis. FIGURE 15.23 Natural Killer (NK) Cells Destroy Stressed "Self" Cells That Lack MHC Class I Molecules
Nucleotides
It is an organic molecule made up of three basic components- a nitrogenous base, phosphate,and pentose sugar. The nucleotides are important for metabolic reactions andthe formation of DNA (deoxyribonucleic acid) and RNA (ribonucleic acid).
Nucleic Acids
Nucleic acids are essential biomolecules present in prokaryotic and eukaryotic cells and viruses. They carry the genetic information for the synthesis of proteins and cellular replication. The nucleic acids are of two types: deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). The structure of all proteins and ultimately every biomolecule and cellular component is a product of information encoded in the sequence of nucleic acids. Parts of a DNA molecule containing the information needed to synthesize a protein or an RNA are genes. Nucleic acids can store and transmit genetic information from one generation to the next, fundamental to any life form.
Why would a virus that can interfere with a host cell’s production of MHC class I molecules be at an advantage?
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