(a)
Interpretation:
The synthesis of acetoacetic ester can be used to prepare 5-phenyl-2,5-pentanedione has to be showed.
Concept Introduction:
Acetoacetic ester is a versatile starting material for the formation of new carbon-carbon bonds. It is because of the presence of acidic α-hydrogens between two carbonyl groups, the nucleophilicity of the enolate anion formed by the loss of α-hydrogen and the ability of the product to undergo decarboxylation after hydrolysis of ester.
(b)
Interpretation:
The synthesis of acetoacetic ester can be used to prepare 1-cyclopentyl-1-ethanone has to be showed.
Concept Introduction:
Acetoacetic ester is a versatile starting material for the formation of new carbon-carbon bonds. It is because of the presence of acidic α-hydrogens between two carbonyl groups, the nucleophilicity of the enolate anion formed by the loss of α-hydrogen and the ability of the product to undergo decarboxylation after hydrolysis of ester.
(c)
Interpretation:
The synthesis of acetoacetic ester can be used to prepare 3-ethyl-2-pentanone has to be showed.
Concept Introduction:
Acetoacetic ester is a versatile starting material for the formation of new carbon-carbon bonds. It is because of the presence of acidic α-hydrogens between two carbonyl groups, the nucleophilicity of the enolate anion formed by the loss of α-hydrogen and the ability of the product to undergo decarboxylation after hydrolysis of ester.
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Chapter 19 Solutions
EP ORGANIC CHEMISTRY-OWL V2 ACCESS
- What are steps in acid-catalyzed ester hydrolysis ?arrow_forwardI am very confused and I want to study so please help me with these problemsarrow_forwardTwo reactions occur when sodium hydroxide is added to methyl salicylate. One is immediate and one only occurs with reflux over time. What type of reaction occurs immediately and with which functional group on methyl salicylate does it react? What type of reaction occurs with reflux over time and with which functional group on methyl salicylate does it react?arrow_forward
- What products are formed by acidic hydrolysis of the following compound? benzaldehyde and butan-1-d benzeie acid and butan-2-d 2-methylbutanoic acid and phenol benzoic acid and methyl ethyl ketonearrow_forwardDraw the mechanism for acid-catalyzed ester hydrolysis.arrow_forwardIn a base catalyzed keto-enol tautomerization of an aldehyde the first step of the mechanism is removal of the proton from the alpha carbon. removal for a proton from the carbonyl carbon. protonation of the carbonyl carbon. protonation of the carbonyl oxygen.arrow_forward
- Which of these is the most viable route for the preparation or synthesis of a carboxylic acid? O Alpha-carbon substitution of ketones O Oxidation of aldehydes O Nucleophilic acyl substitution of amides O Elimination of alcohols O Nucleophilic addition of ketonesarrow_forward5. Make the following via acetoacetic ester synthesis. شد کاarrow_forwardDraw the structure for the following compounds It organic 1: 2,2 diiodo-3-pentenoic acid 2: N,N-diethylpropanamide 3: 2-pentanone 4: phenoxy benzene 5: N,N-diethylpropanamidearrow_forward
- What products are formed when all of the amide and ester bonds are hydrolyzed in each of the following compounds? Tamiflu [part (a)] is the trade name of the antiviral agent oseltamivir, thought to be the most effective agent in treating influenza. Aspartame [part (b)] is the artificial sweetener used in Equal and many diet beverages. One of the products of this hydrolysis reaction is the amino acid phenylalanine. Infants afflicted with phenylketonuria cannot metabolize this amino acid, so it accumulates, causing mental retardation. When the affliction is identified early, a diet limiting the consumption of phenylalanine (and compounds like aspartame that are converted to it) can make a normal life possible.arrow_forwardThe following molecule undergoes an intramolecular reaction in the presence of pyrrolidinium acetate, the protonated form of pyrrolidine. Draw the product of this reaction, assuming that a dehydration reaction takes place.arrow_forward18-28 Arrange these compounds in order of increasing acidity: benzoic acid, benzyl alcohol, phenol.arrow_forward
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