Concept explainers
(a)
Interpretation:
The preparation of the below given compound using directed aldol reactions has to be given.
Concept Introduction:
In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.
LDA (Lithium diisopropylamide) is a strong base. It converts
(b)
Interpretation:
The preparation of the below given compound using directed aldol reactions has to be given.
Concept Introduction:
In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.
LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.
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Chapter 19 Solutions
EP ORGANIC CHEMISTRY-OWL V2 ACCESS
- Show how to synthesize the following compound from an alkyl halide and a ketone oraldehyde. Hint: use a Wittig reaction.arrow_forwardShow how the following targets can be formed via an aldol reaction oftwo carbonyl compounds using retrosynthesis.arrow_forwardShow how to prepare a,b-unsaturated ketone by an aldol reaction followed by dehydration of the aldol product.arrow_forward
- Propose a crossed aldol reaction where the following compound would be the only product. Propose a mechanism for the reaction. OHarrow_forwardShow the mechanism of the given aldol reaction.arrow_forwardPropose an efficient synthesis for the following transformations using ONLY aldol, micheal and other reactions related to enol/enolate.arrow_forward
- Show how you could achieve the following transformation. Be sure to show the product produced after each reaction. You do not need to show mechanisms or a retrosynthesisarrow_forward3. Show how the following compound can be synthesized using an Aldol Condensation reaction.arrow_forwardPropose a synthesis of the following molecule using an aldol reaction.arrow_forward
- What starting materials are needed to synthesize each compound using an aldol or similar reaction?arrow_forwardPlan a synthesis that converts the given starting material into the desired product. More thanone step may be required.arrow_forwardPropose a two-step synthesis for the following transformation. HOʻarrow_forward
- Organic Chemistry: A Guided InquiryChemistryISBN:9780618974122Author:Andrei StraumanisPublisher:Cengage Learning
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