The preparation of the below given compound using directed aldol reactions has to be given. Concept Introduction: In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate. LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes , ketones and esters into their enolate anions.

Question

Complete the following table. The only density needed is already given. Show your calculations in a neat and easy-to-follow manner in the space below the table. All units should be included and significant figures should be given close attention. Be sure to notice that the amount of material should be in millimoles rather than moles, and the theoretical mass of the product should in milligrams rather than grams. LOCH 3 + H2SO4 HNO 3 O=C-OCH 3 NO2 x H₂O F.W. 4.0 mL 1.3 M amount 0.50 mL in H2SO4 mg Theoretical Theoretical mmoles density 1.09

Answer 1

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Students have asked these similar questions

Complete the following table. The only density needed is already given. Show your calculations in a neat and easy-to-follow manner in the space below the table. All units should be included and significant figures should be given close attention. Be sure to notice that the amount of material should be in millimoles rather than moles, and the theoretical mass of the product should in milligrams rather than grams. LOCH 3 + H2SO4 HNO 3 O=C-OCH 3 NO2 x H₂O F.W. 4.0 mL 1.3 M amount 0.50 mL in H2SO4 mg Theoretical Theoretical mmoles density 1.09

Kumada Coupling: 1. m-Diisobutylbenzene below could hypothetically be synthesized by Friedel-Crafts reaction. Write out the reaction with a mechanism and give two reasons why you would NOT get the desired product. Draw the reaction (NOT a mechanism) for a Kumada coupling to produce the molecule above from m-dichlorobenzene. Calculate the theoretical yield for the reaction in question 2 using 1.5 g of p-dichlorobenzene and 3.0 mL isobutyl bromide. What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What other impurities are present in your product and how do you know?

Wintergreen from Aspirin: 1. In isolating the salicylic acid, why is it important to press out as much of the water as possible? 2. Write the mechanism of the esterification reaction you did. 3. What characteristic absorption band changes would you expect in the IR spectrum on going from aspirin to salicyclic acid and then to methyl salicylate as you did in the experiment today? Give approximate wavenumbers associated with each functional group change. What signals appeared/disappeared/shifted that indicate that you have your intended product and not starting material? What other impurities are present in your product and how do you know?

Answer 2

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 3

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

(b)

Interpretation Introduction

Interpretation:

The preparation of the below given compound using directed aldol reactions has to be given.

Concept Introduction:

In directed aldol reactions, the enolate anion is prepared with one carbonyl compound by LDA (Lithium diisopropylamide). The other carbonyl compound acts as an electrophile. Both of the carbonyl compounds have α-hydrogens, but only one enolate is prepared using LDA. When unsymmetrical ketone is used, it forms less substituted enolate.

LDA (Lithium diisopropylamide) is a strong base. It converts aldehydes, ketones and esters into their enolate anions.

Expert Solution & Answer

Trending nowThis is a popular solution!

See solution

Check out sample textbook solution

Answer 4

Question

Definition Definition Organic compounds that have a carbonyl group, C=O, as their functional group. The carbonyl group in aldehydes is placed at the end of the molecular structure, which means the C=O is attached to one hydrogen atom and an alkyl group or a benzene ring. Just like all the other homologous series in organic chemistry, the naming of aldehydes uses the suffix “-al”. The general molecular formula is C n H 2n O.

Chapter 19.9, Problem 19.17P

(a)

Interpretation Introduction