
(a) Interpretation:
Substrate required by B enzyme should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen.Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(b) Interpretation:
Compound excreted in urine because ofenzyme C deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(c) Interpretation:
Consistent alterations of genetic in the enzyme because of treatment by injecting B12 for the enzyme C deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.
(d) Interpretation:
Kinds of amino acid released during urine excretion of animals having genetic deficiency in animals should be identified.
Concept Introduction:
Biosynthesis of vitamin B12 or cobalamin has aerobic and anaerobic pathways. Aerobic is where the chemical pathway needs oxygen and later cobalt is added. In anaerobic pathway, cobalt is added in the beginning and requires no oxygen. Biosynthesis of B12 as shown in the diagram produces 5-methyltetrahydrofolate as substrate. And methylmalonate is the compound formed in genetic deficient animal's urine. When the C enzyme loses its affinity towards a substrate injecting large amount of Vitamin B12 is reduced. Homocysteine is released during urine excretion.

Want to see the full answer?
Check out a sample textbook solution
Chapter 18 Solutions
BIOCHEMISTRY BOOKS ALC&MOD MST/ET PKG
- Which type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.arrow_forward+NH+ CO₂ +P H₂N + ATP H₂N NH₂ +ADParrow_forwardWhich type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.arrow_forward
- Which features of the curves in Figure 30-2 indicates that the enzyme is not consumed in the overall reaction? ES is lower in energy that E + S and EP is lower in energy than E + P. What does this tell you about the stability of ES versus E + S and EP versus E + P.arrow_forwardLooking at the figure 30-5 what intermolecular forces are present between the substrate and the enzyme and the substrate and cofactors.arrow_forwardprovide short answers to the followings Urgent!arrow_forward
- Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvatedehydrogenase complex, resulting in acetyl-CoA and CO2. Provide a full mechanismfor this reaction utilizing the TPP cofactor. Include the roles of all cofactors.arrow_forwardB- Vitamins are converted readily into important metabolic cofactors. Deficiency inany one of them has serious side effects. a. The disease beriberi results from a vitamin B 1 (Thiamine) deficiency and ischaracterized by cardiac and neurological symptoms. One key diagnostic forthis disease is an increased level of pyruvate and α-ketoglutarate in thebloodstream. How does this vitamin deficiency lead to increased serumlevels of these factors? b. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 5 deficiency? c. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 2 /B 3 deficiency?arrow_forwardDraw the Krebs Cycle and show the entry points for the amino acids Alanine,Glutamic Acid, Asparagine, and Valine into the Krebs Cycle - (Draw the Mechanism). How many rounds of Krebs will be required to waste all Carbons of Glutamic Acidas CO2?arrow_forward
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON





