Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 17, Problem 5P
The fly eyes shown in Fig. 17.6 (p. 580) are malformed because they lack a functional copy of a gene called fat facets that is required for eye development. The human genome encodes a protein called Usp9 that is similar in amino acid sequence to the fly Fat facets (Faf) protein. Likewise, the mouse genome encodes a protein called Fam that is similar to Faf and Usp9.
| a. | How could you determine if human Usp9 can substitute for the Drosophila Faf protein? |
| b. | How could you determine if, like Faf in flies, the mouse Fam protein is required for mouse eye development? |
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Using information from the primary literature (several references have been provided as a starting point below) please answer the following question: Based on your review of the literature on rewilding, what are the major scientific pros and cons for rewilding?
Please note that the focus of this assignment are the (biological) scientific issues associated with rewilding. As will be discussed in class, there are a number of non-scientific issues involved or implicated in rewilding, all ultimately affecting the public acceptability of rewilding. Although these issues are important – indeed, critical – in this assignment you should focus on the biological science issues and questions.
Details:
You must enumerate at least two pros and at least two cons.
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Chapter 17 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 17 - Match each of the terms in the left column to the...Ch. 17 - Mice are usually gray, but a mouse geneticist has...Ch. 17 - Sometimes, genes transferred into the mouse genome...Ch. 17 - In mice, a group of so-called Hox genes encode...Ch. 17 - The fly eyes shown in Fig. 17.6 p. 580 are...Ch. 17 - Prob. 6PCh. 17 - Fish and other organisms that live in the Arctic...Ch. 17 - Prob. 8PCh. 17 - The first page of this chapter p. 575 shows a...Ch. 17 - The goal of the Knockout Mouse Project is to...
Ch. 17 - Prob. 11PCh. 17 - Recall that constructs used for floxing a gene...Ch. 17 - a. Which genome manipulation technique would you...Ch. 17 - a. Diagram a knockin construct that could have...Ch. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - A transcription factor Pax6 is required...Ch. 17 - Mouse models for human genetic diseases are...Ch. 17 - One way to determine where inside a cell a protein...Ch. 17 - Prob. 20PCh. 17 - Prob. 21PCh. 17 - Recall that Leber congenital amaurosis LCA, a form...Ch. 17 - One potential strategy for gene therapy to correct...
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