Genetics: From Genes to Genomes, 5th edition
5th Edition
ISBN: 9780073525310
Author: Leland H. Hartwell, Michael L. Goldberg, Janice A. Fischer, Leroy Hood, Charles F. Aquadro
Publisher: McGraw-Hill Education
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Chapter 17, Problem 13P
| a. | Which genome manipulation technique would you use to create a mouse model for the human disease Leber congenital amaurosis (LCA), described at the beginning of the chapter on p. 575? Explain. |
| b. | Which procedure would you use to generate a mouse model for fragile X syndrome, a triplet repeat disease caused by a mutant allele of the FMR-1 gene? (Review the Fast Forward Box in Chapter 7 on p. 216.) Explain. |
| c. | Which procedure would you use to create a mouse model for Huntington disease? |
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Using information from the primary literature (several references have been provided as a starting point below) please answer the following question: Based on your review of the literature on rewilding, what are the major scientific pros and cons for rewilding?
Please note that the focus of this assignment are the (biological) scientific issues associated with rewilding. As will be discussed in class, there are a number of non-scientific issues involved or implicated in rewilding, all ultimately affecting the public acceptability of rewilding. Although these issues are important – indeed, critical – in this assignment you should focus on the biological science issues and questions.
Details:
You must enumerate at least two pros and at least two cons.
Your answer should be no more than 500 well-chosen words, excluding references. Think carefully about how best to organize and structure your answer. Aim for high information density: say a lot, but say it succinctly. Recall Nietzche’s…
Chapter 17 Solutions
Genetics: From Genes to Genomes, 5th edition
Ch. 17 - Match each of the terms in the left column to the...Ch. 17 - Mice are usually gray, but a mouse geneticist has...Ch. 17 - Sometimes, genes transferred into the mouse genome...Ch. 17 - In mice, a group of so-called Hox genes encode...Ch. 17 - The fly eyes shown in Fig. 17.6 p. 580 are...Ch. 17 - Prob. 6PCh. 17 - Fish and other organisms that live in the Arctic...Ch. 17 - Prob. 8PCh. 17 - The first page of this chapter p. 575 shows a...Ch. 17 - The goal of the Knockout Mouse Project is to...
Ch. 17 - Prob. 11PCh. 17 - Recall that constructs used for floxing a gene...Ch. 17 - a. Which genome manipulation technique would you...Ch. 17 - a. Diagram a knockin construct that could have...Ch. 17 - Prob. 15PCh. 17 - Prob. 16PCh. 17 - A transcription factor Pax6 is required...Ch. 17 - Mouse models for human genetic diseases are...Ch. 17 - One way to determine where inside a cell a protein...Ch. 17 - Prob. 20PCh. 17 - Prob. 21PCh. 17 - Recall that Leber congenital amaurosis LCA, a form...Ch. 17 - One potential strategy for gene therapy to correct...
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- What is produced inside the indicated structure (Fucus). a. eggs O b. antheridia ○ c. sperm d. zygotes e. none of thesearrow_forwardGreen Algae, as a group, is actually paraphyletic with one subgroup more closely related to higher plants than the other. Which of the following green algae groups is more closely related to higher plants: a. Charophyceans b. Chlorophyceans c. Rhodophyta d. Xanthophyceansarrow_forwardA single-celled green algal genus that is motile with 2 flagella, has a cup shaped chloroplast, and an eyespot: a. Volvox b. Chlamydomonas c. Euglena d. Codiumarrow_forward
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