Biology: Concepts and Investigations
4th Edition
ISBN: 9780078024207
Author: Mariëlle Hoefnagels Dr.
Publisher: McGraw-Hill Education
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Textbook Question
Chapter 17, Problem 2PIT
Add autotrophs, heterotrophs, phototrophs, and chemotrophs 10 this concept map.
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Digoxin: Intravenous Bolus - Two Compartment Model
Drug
Digoxin
Route:
IV Bolus
Dose:
0.750 mg
Plasma Concentration Time Profile
Beta
Alpha
Time (hrs)
Conc (ng/ml)
LN
(ng/ml)
LN
(ng/ml)
LN
0.00
#NUM!
#NUM!
#NUM!
0.10
12.290
2.509
#NUM!
#NUMI
0.60
6.975
1.942
#NUM!
#NUMI
1.00
4.649
1.537
#NUM!
#NUMI
2.00
2.201
0.789
#NUM!
#NUM!
3.00
1.536
0.429
#NUM!
#NUM!
4.00
1.342
0.294
#NUM!
#NUM!
5.00
1.273
0.241
#NUM!
#NUMI
6.00
1.238
0.213
#NUM!
#NUM!
7.00
1.212
0.192
#NUM!
#NUM!
8.00
1.188
0.172
#NUMI
#NUM!
9.00
1.165
0.153
#NUM!
#NUMI
10.00
1.143
0.134
#NUMI
#NUM!
11.00
1.122
0.115
#NUM!
12.00
1.101
0.096
#NUMI
13.00
1.080
0.077
#NUMI
16.00
1.020
0.020
#NUMI
24.00
0.876
-0.132
#NUMI
Pharmacokinetic Parameters
Parameter
Value
Alpha
B
Beta
Units
ng/ml
hr-1
ng/ml
hr-1
CO
ng/ml
H.C
AUC
ng x hr/ml
Vc
Vbeta
Vss
C
L/hr
TK (alpha)
hr
TX (beta)
days
5+
F3
F4
F5
0+
F6
F7
%
6
95
14
#3
29
&
t
F8
F9
FW
EW
Linuron, a derivative of urea, is used as an herbicide. Linuron serum levels were measured in 4Kg
rabbits following a bolus IV injection of 10mg/kg.
Time (minutes)
Serum Linuron Levels (ug/ml)
following IV dose
10
15.48
20
8.60
30
5.90
45
3.78
60
2.42
90
1.49
120
0.93
180
0.60
240
0.41
300
0.29
360
0.22
Analyze this data and perform the necessary calculations to determine the following pharmacokinetic
parameters from the IV data: (5 points per parameter, 24 parameters/variables ■ 120 points
possible). You do NOT need to submit graphs or data tables.
Give the terminal regression line equation and R or R² value:
Give the x axis (name and units, if any) of the terminal line:
Give the y axis (name and units, if any) of the terminal line:
Give the residual regression line equation and R or R² value:
Give the x axis (name and units, if any) of the residual line:
Give the y axis (name and units, if any) of the residual line:
Chapter 17 Solutions
Biology: Concepts and Investigations
Ch. 17.1 - What are two domains that contain prokaryotes?Ch. 17.1 - Prob. 2MCCh. 17.1 - Prob. 3MCCh. 17.1 - Why are most species of prokaryotes little...Ch. 17.2 - Prob. 1MCCh. 17.2 - Prob. 2MCCh. 17.2 - What does the Gram stain reveal about a cell?Ch. 17.2 - Prob. 4MCCh. 17.2 - How are molecular data changing microbial...Ch. 17.2 - Prob. 6MC
Ch. 17.3 - Prob. 1MCCh. 17.3 - Prob. 2MCCh. 17.3 - Prob. 3MCCh. 17.4 - Prob. 1MCCh. 17.4 - Prob. 2MCCh. 17.4 - What adaptations enable pathogenic bacteria to...Ch. 17.4 - What are some practical uses of bacteria and...Ch. 17.5 - Prob. 1MCCh. 17.5 - Prob. 2MCCh. 17 - A prokaryotic cell is one that a. lacks DNA. b....Ch. 17 - Which of these is a distinguishing characteristic...Ch. 17 - What feature distinguishes the cell walls of...Ch. 17 - What type of organism may use inorganic chemicals...Ch. 17 - Prob. 5MCQCh. 17 - Prob. 6MCQCh. 17 - Prob. 7MCQCh. 17 - Prob. 8MCQCh. 17 - Explain why the antibiotics penicillin and...Ch. 17 - Why do some microbiologists disagree with...Ch. 17 - Give five examples that illustrate how bacteria...Ch. 17 - If you were developing a new "broad-spectrum"...Ch. 17 - Describe your own metabolic classification: Are...Ch. 17 - A prokaryote with which type of metabolism would...Ch. 17 - Ernst Mayr defined a biological species as a...Ch. 17 - Why did the discovery of archaea generate interest...Ch. 17 - In an article in Nature magazine, Sean Nee wrote...Ch. 17 - Ecosystems rely on nitrogen -fixing bacteria,...Ch. 17 - Prob. 11WIOCh. 17 - Prob. 12WIOCh. 17 - Prob. 13WIOCh. 17 - Prob. 14WIOCh. 17 - Prob. 15WIOCh. 17 - Mycobacterium tuberculosis causes most cases of...Ch. 17 - Prob. 1PITCh. 17 - Add autotrophs, heterotrophs, phototrophs, and...Ch. 17 - Prob. 3PITCh. 17 - Create a new concept map that includes the...Ch. 17 - Prob. 4PITCh. 17 - Prob. 6PIT
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