Biology: The Unity and Diversity of Life (MindTap Course List)
Biology: The Unity and Diversity of Life (MindTap Course List)
14th Edition
ISBN: 9781305073951
Author: Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr
Publisher: Cengage Learning
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Chapter 17, Problem 2DAA
Summary Introduction

To determine: The town with the highest percentage of poison-resistant wild rats.

Introduction: Rodenticides are the pesticides that have a capability to kill the whole rodent species. Rodents have their own importance in the nature but sometimes require some control over their population, as they could transmit disease, destroy crops, and may cause ecological damage. Warfarin is a common anticoagulant that could be used as rodenticide to kill mice and rats.

After the discovery, warfarin has been widely used and later it resulted in the development of species of warfarin-resistant mice and rats. Another recently developed one is bromadiolone, which is called as the super-warfarin (second-generation warfarin) that has a greater ability to accumulate in the liver and kill the organism.

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a. What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent.  b. What will happen to elimination of the drug in the previous question if the system is saturated? explain and show any math involved
If you wanted to reduce the difference between peak and trough levels that occur with repeated administration of a drug, how would you adjust the dose and dose interval without changing the plateau concentration (plateau is the average of peak and trough levels)? Select your answers for both dose and interval. Hint: It may be helpful to think about this problem using an example such as food. How would you eat if you wanted to maintain very steady hunger/satiety levels without changing your total caloric intake? Options: A. Dose; Increase dose     B. Dose; Decrease dose     C. Dose; Do not change dose     D. Interval; Increase the interval between doses (give the drug less frequently)    E. Interval; Decrease the interval between doses (give the drug more frequently)     F. Interval; Do not change the interval
What percentage of a drug is eliminated after 4 half-lives? Please round to the nearest percent. Show the math
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