FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
5th Edition
ISBN: 9781119661450
Author: Voet
Publisher: WILEY
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 17, Problem 27CQ
Summary Introduction
To explain: The inhibition of phosphofructokinase is advantageous for citrate.
Concept introduction: Citrate is the allosteric inhibitor of phosphofructokinase. It inactivates phosphofructokinase when its concentration is high, but not when citrate concentration is low.
Expert Solution & Answer

Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
Which type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.
+NH+
CO₂
+P
H₂N
+ ATP
H₂N
NH₂
+ADP
Which type of enzyme catalyses the following reaction? oxidoreductase, transferase, hydrolase, lyase, isomerase, or ligase.
Chapter 17 Solutions
FUNDAMENTALS OF BIOCHEM.-NEXTGEN ACCESS
Ch. 17 - Prob. 1ECh. 17 - 2. If acetyl-CoA is labeled with l4C at its methyl...Ch. 17 - 3. List four possible metabolic fates for pyruvate...Ch. 17 - 4. Explain why metabolic acidosis (Box 2-2) may...Ch. 17 - 5. Which one of the live steps of the pyruvate...Ch. 17 - Prob. 6ECh. 17 - 7. Photosynthetic organisms use elaborate...Ch. 17 - 6. Does the pyruvate-formate lyase reaction...Ch. 17 - Prob. 9ECh. 17 - Prob. 10E
Ch. 17 - Prob. 11ECh. 17 - 12. What citric acid cycle intermediates would...Ch. 17 - Prob. 13ECh. 17 - Prob. 14ECh. 17 - Prob. 15ECh. 17 - 16. What is the ratio of [isocitrate] to [citrate]...Ch. 17 - 17. Explain why a deficiency of pyruvate...Ch. 17 - Prob. 18ECh. 17 - Prob. 19ECh. 17 - Prob. 20ECh. 17 - 21. Helicobacter pylori, which causes gastric...Ch. 17 - Prob. 22ECh. 17 - Prob. 23CQCh. 17 - 24. Which compounds would accumulate in an...Ch. 17 - Prob. 25CQCh. 17 - 26. Certain microorganisms with an incomplete...Ch. 17 - Prob. 27CQCh. 17 - Prob. 28CQCh. 17 - Prob. 29CQCh. 17 - Prob. 30CQCh. 17 - 31. Anaplerotic reactions permit the citric acid...Ch. 17 - 32. Although animals cannot synthesize glucose...Ch. 17 - Prob. 33CQCh. 17 - Prob. 34CQCh. 17 - Prob. 35CQCh. 17 - 36. Acetyl-CoA, in addition to providing 2-carbon...Ch. 17 - Prob. 1MTE
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biochemistry and related others by exploring similar questions and additional content below.Similar questions
- Which features of the curves in Figure 30-2 indicates that the enzyme is not consumed in the overall reaction? ES is lower in energy that E + S and EP is lower in energy than E + P. What does this tell you about the stability of ES versus E + S and EP versus E + P.arrow_forwardLooking at the figure 30-5 what intermolecular forces are present between the substrate and the enzyme and the substrate and cofactors.arrow_forwardprovide short answers to the followings Urgent!arrow_forward
- Pyruvate is accepted into the TCA cycle by a “feeder” reaction using the pyruvatedehydrogenase complex, resulting in acetyl-CoA and CO2. Provide a full mechanismfor this reaction utilizing the TPP cofactor. Include the roles of all cofactors.arrow_forwardB- Vitamins are converted readily into important metabolic cofactors. Deficiency inany one of them has serious side effects. a. The disease beriberi results from a vitamin B 1 (Thiamine) deficiency and ischaracterized by cardiac and neurological symptoms. One key diagnostic forthis disease is an increased level of pyruvate and α-ketoglutarate in thebloodstream. How does this vitamin deficiency lead to increased serumlevels of these factors? b. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 5 deficiency? c. What would you expect the effect on the TCA intermediates for a patientsuffering from vitamin B 2 /B 3 deficiency?arrow_forwardDraw the Krebs Cycle and show the entry points for the amino acids Alanine,Glutamic Acid, Asparagine, and Valine into the Krebs Cycle - (Draw the Mechanism). How many rounds of Krebs will be required to waste all Carbons of Glutamic Acidas CO2?arrow_forward
- Sodium fluoroacetate (FCH 2CO2Na) is a very toxic molecule that is used as rodentpoison. It is converted enzymatically to fluoroacetyl-CoA and is utilized by citratesynthase to generate (2R,3S)-fluorocitrate. The release of this product is a potentinhibitor of the next enzyme in the TCA cycle. Show the mechanism for theproduction of fluorocitrate and explain how this molecule acts as a competitiveinhibitor. Predict the effect on the concentrations of TCA intermediates.arrow_forwardIndicate for the reactions below which type of enzyme and cofactor(s) (if any) wouldbe required to catalyze each reaction shown. 1) Fru-6-P + Ery-4-P <--> GAP + Sed-7-P2) Fru-6-P + Pi <--> Fru-1,6-BP + H2O3) GTP + ADP <--> GDP + ATP4) Sed-7-P + GAP <--> Rib-5-P + Xyl-5-P5) Oxaloacetate + GTP ---> PEP + GDP + CO 26) DHAP + Ery-4-P <--> Sed-1,7-BP + H 2O7) Pyruvate + ATP + HCO3- ---> Oxaloacetate + ADP + Piarrow_forwardTPP is also utilized in transketolase reactions in the PPP. Give a mechanism for theTPP-dependent reaction between Xylulose-5-phosphate and Ribose-5-Phosphate toyield Glyceraldehyde-3-phosphate and Sedoheptulose-7-Phosphate.arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- BiochemistryBiochemistryISBN:9781319114671Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.Publisher:W. H. FreemanLehninger Principles of BiochemistryBiochemistryISBN:9781464126116Author:David L. Nelson, Michael M. CoxPublisher:W. H. FreemanFundamentals of Biochemistry: Life at the Molecul...BiochemistryISBN:9781118918401Author:Donald Voet, Judith G. Voet, Charlotte W. PrattPublisher:WILEY
- BiochemistryBiochemistryISBN:9781305961135Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougalPublisher:Cengage LearningBiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage LearningFundamentals of General, Organic, and Biological ...BiochemistryISBN:9780134015187Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. PetersonPublisher:PEARSON

Biochemistry
Biochemistry
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:W. H. Freeman

Lehninger Principles of Biochemistry
Biochemistry
ISBN:9781464126116
Author:David L. Nelson, Michael M. Cox
Publisher:W. H. Freeman

Fundamentals of Biochemistry: Life at the Molecul...
Biochemistry
ISBN:9781118918401
Author:Donald Voet, Judith G. Voet, Charlotte W. Pratt
Publisher:WILEY

Biochemistry
Biochemistry
ISBN:9781305961135
Author:Mary K. Campbell, Shawn O. Farrell, Owen M. McDougal
Publisher:Cengage Learning

Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning

Fundamentals of General, Organic, and Biological ...
Biochemistry
ISBN:9780134015187
Author:John E. McMurry, David S. Ballantine, Carl A. Hoeger, Virginia E. Peterson
Publisher:PEARSON
Macromolecules | Classes and Functions; Author: 2 Minute Classroom;https://www.youtube.com/watch?v=V5hhrDFo8Vk;License: Standard youtube license