Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 17, Problem 25ESP

Regulation of the lac operon in E. coli (see Chapter 16) and regulation of the GAL system in yeast are analogous in that they both serve to adapt cells to growth on different carbon sources. However, the transcriptional changes are accomplished very differently. Consider the conceptual similarities and differences as you address the following.

  1. (a) Compare and contrast the roles of the lac operon inducer in bacteria and Gal3p in eukaryotes in the regulation of their respective systems.
  2. (b) Compare and contrast the cis-regulatory elements of the lac operon and GAL gene system.
  3. (c) Compare and contrast how these two systems are negatively regulated such that they are downregulated in the presence of glucose.
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Concepts of Genetics (12th Edition)

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