Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Textbook Question
Chapter 17, Problem 13PDQ
Describe the manner in which activators and repressors influence the rate of transcription initiation. How might chromatin structure be involved in such regulation?
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Which is the expected outcome following the deacetylation of histones?
a) Coiling of chromatin, preventing it from being accessed by transcriptional machinery
b) Coiling of chromatin, allowing it to be accessed by transcriptional machinery
c) Uncoiling of chromatin, preventing it from being accessed by transcriptional machinery
d) Uncoiling of chromatin, allowing it to be accessed by transcriptional machinery
Where in the many steps of transcription initiation does regulation occur?
Describe three ways that the function of a regulatory transcription factor can be modulated.
Chapter 17 Solutions
Concepts of Genetics (12th Edition)
Ch. 17 - Cancer cells often have abnormal patterns of...Ch. 17 - The hormone estrogen converts the estrogen...Ch. 17 - Each year in the United States, there are over...Ch. 17 - Prob. 2CSCh. 17 - Each year in the United States, there are over...Ch. 17 - HOW DO WE KNOW? In this chapter, we focused on how...Ch. 17 - CONCEPT QUESTION Review the Chapter Concepts list...Ch. 17 - What features of eukaryotes provide additional...Ch. 17 - Provide a definition of chromatin remodeling, and...Ch. 17 - Describe the organization of the interphase...
Ch. 17 - A number of experiments have demonstrated that...Ch. 17 - Provide a brief description of two different types...Ch. 17 - Present an overview of the manner in which...Ch. 17 - Prob. 9PDQCh. 17 - Explain how the addition of acetyl groups to...Ch. 17 - Distinguish between the cis-acting regulatory...Ch. 17 - Prob. 12PDQCh. 17 - Describe the manner in which activators and...Ch. 17 - Compare the control of gene regulation in...Ch. 17 - Many promoter regions contain CAAT boxes...Ch. 17 - Prob. 16PDQCh. 17 - Prob. 17PDQCh. 17 - Many transcriptional activators are proteins with...Ch. 17 - Prob. 19PDQCh. 17 - DNA supercoiling, which occurs when coiling...Ch. 17 - Prob. 21ESPCh. 17 - Prob. 22ESPCh. 17 - Because the degree of DNA methylation appears to...Ch. 17 - A particular type of anemia in humans, called...Ch. 17 - Regulation of the lac operon in E. coli (see...Ch. 17 - DNA methylation is commonly associated with a...Ch. 17 - During an examination of the genomic sequences...Ch. 17 - Prob. 28ESPCh. 17 - Although a single activator may bind many...Ch. 17 - Hereditary spherocytosis (HS) is a disorder...Ch. 17 - Transcription factors play key roles in the...
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- Explain the binding of transcription regulatory proteins to DNA ?arrow_forwardWhat are general transcription factors? When do you expect to find them? What is a cis acting regulatory sequence? Where are they located in comparison with the gene they are regulating?arrow_forwardPresent an overview of the manner in which chromatin can be remodeled. Describe the manner in which these remodeling processes influence transcription.arrow_forward
- Describe the manner in which activators and repressors influencethe rate of transcription initiation. How might chromatinstructure be involved in such regulation?arrow_forwardWhat are the role of transcription proteins? Explain briefly at your own wordsarrow_forwardDescribe events associated with the process of transcription in eukaryotic cells. How is the process different in prokaryotic cells?arrow_forward
- What is the role of chromatin modification in transcription?arrow_forwardIn eukaryotic transcription, what is the function of a histone chaperone? Of a chromatin remodeling complex? Of Mediator?arrow_forwardDefine how Activators and Repressors Interact with General TranscriptionFactors ?arrow_forward
- Describe the function of eukaryotic enhancers in transcription.arrow_forwardTranscriptional regulators are proteins that bind to promoters (at the 5’ flanking regions of genes) to regulate their transcription. Assume that a particular transcription regulator normally promotes transcription of gene X that codes for a membrane transport protein. If a mutation makes this transcription regulator nonfunctional, would the resulting phenotype be similar to a deleterious mutation in the membrane transporter itself? Why or why not?arrow_forwardDescribe three types of post-transcriptional regulation of protein coding genes.arrow_forward
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