Concepts of Genetics (12th Edition)
Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 17, Problem 1PDQ

HOW DO WE KNOW? In this chapter, we focused on how eukaryotic genes are regulated at the transcriptional level. Along the way, we found many opportunities to consider the methods and reasoning by which much of this information was acquired. From the explanations given in the chapter,

  1. (a) How do we know that promoter and enhancer sequences control the initiation of transcription in eukaryotes?
  2. (b) How do we know that the orientation of promoters relative to the transcription start site is important while enhancers are orientation independent?
  3. (c) How do we know that eukaryotic transcription factors bind to DNA sequences at or near promoter regions?
  4. (d) How do we know that there is an association between disease susceptibility in humans and regulatory DNA sequences?
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Concepts of Genetics (12th Edition)

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